776313-08-7Relevant articles and documents
Copper-mediated selective C-H activation and cross-dehydrogenative C-N coupling of 2′-aminoacetophenones
Ilangovan, Andivelu,Satish, Gandhesiri
supporting information, p. 5726 - 5729 (2013/12/04)
Isatins were obtained by cross-dehydrogenative C-N annulation and dealkylative C-N annulation of 2′-N-aryl/alkylaminoacetophenones and 2′-N,N-dialkylaminoacetophenones respectively in the presence of Cu(OAc)2·H2O/NaOAc/air. However, on reaction with CuBr, 2′-N-benzylaminoacetophenones underwent selective oxidation of an α-methylene group of amine rather than the 2-acetyl group to provide corresponding benzamides exclusively. Base played an important role in selective oxidation by lowering the temperature and time.
α-Glucosidase inhibition of 6-hydroxyflavones. Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as α-glucosidase inhibitors
Gao, Hong,Kawabata, Jun
, p. 1661 - 1671 (2007/10/03)
The SAR studies suggested that the C-ring of baicalein (1) was not necessary for the activity, and validated the importance of 2,3,4- trihydroxybenzoyl structure of 1. Thus, a series of 2,3,4-trihydroxybenzoyl- containing flavonoid analogs were investigat
Antimitotic activity of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones
Hadjeri, Mohamed,Peiller, Eva-Laure,Beney, Chantal,Deka, Nabajyoti,Lawson, Martin A.,Dumontet, Charles,Boumendjel, Ahcène
, p. 4964 - 4970 (2007/10/03)
We report the synthesis of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones and their biological activity as antitumor agents. These molecules were initially evaluated for their ability to induce cell cycle arrest in the G2/M phase. Compounds that showed signifi
