77651-72-0

Basic information

• Product Name: 4-Quinazolinamine, N-methyl-2-phenyl-
• CAS NO: 77651-72-0
• Molecular Formula: C15H13N3
• Molecular Weight: 235.288
• Mol File: 77651-72-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Quinazolinamine, N-methyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinazolinamine, N-methyl-2-phenyl-(77651-72-0)
• EPA Substance Registry System: 4-Quinazolinamine, N-methyl-2-phenyl-(77651-72-0)

Safety Data

• Hazardous Substances Data: 77651-72-0(Hazardous Substances Data)

Upstream product

• 6484-25-9 4-chloro-2-phenylquinazoline 
• 74-89-5 methylamine 
• 134-20-3 2-carbomethoxyaniline 
• 70375-39-2 1-methyl-3-[(phenyl)-(phenylimino)methyl]thiourea 
• 593-51-1 methylamine hydrochloride 
• 7510-49-8 methyl 2-(benzamido)benzoate 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase i inhibitors with molecular modeling

4-Amino-2-phenylquinazolines 7 were designed as bioisosteres of 3-arylisoquinolinamines 6 that were energy minimized to provide stable conformers. Interestingly, the 2-phenyl ring of 4-amino-2-phenylquinazolines was parallel to the quinazoline ring and improved their DNA intercalation ability in the DNA-topo I complex. Among the synthesized 4-amino group-substituted analogs, 4-cyclohexylamino-2-phenylquinazoline 7h exhibited potent topo I inhibitory activity and strong cytotoxicity. Interestingly, consistency was observed between the cytotoxicities and topo I activities in these quinazoline analogs, suggesting that the target of 4-amino-2-phenylquinazolines is limited to topo I. Molecular docking studies were performed with the Surflex-Dock program to afford the ideal interaction mode of the compound into the binding site of the DNA-topo I complex in order to clarify the topo I activity of 7h.

Phosphoramides. XIII. Phosphorus Pentaoxide-Amine Hydrochloride Mixtures as Reagents in the Synthesis of 4(3H)-Quinazolinones and 4-Quinazolinamines

4(3H)-Quinazolinones 3a-r have been prepared by heating methyl N-acylanthranilates 1a-c and the hydrochlorides of primary aliphatic and aromatic amines with phosphorus pentaoxide and N,N-dimethylcyclohexylamine at 180 deg C. 4-Quinazolinamines 4 and the amidine 7 were isolated as by-products.The carboxamides 5 and 6 were believed to be reaction intermediates.By raising the temperature to 250 deg C 4 was obtained in a preparative yield.