77726-78-4Relevant articles and documents
Real time HR-MAS NMR: Application in reaction optimization, mechanism elucidation and kinetic analysis for heterogeneous reagent catalyzed small molecule chemistry
Roy, Abhijeet Deb,Jayalakshmi,Dasgupta, Somnath,Roy, Raja,Mukhopadhyay, Balaram
, p. 1119 - 1126 (2008)
A novel application of in situ 1H high-resolution magic angle spinning (HR-MAS) NMR technique for real-time monitoring of H2SO 4-silica promoted formation of 2, 2-disubstituted quinozolin-4(3H)-ones is reported. The detailed NMR spectroscopic data led to elucidation of the mechanism, reaction optimization, kinetics and quantitative analysis of the product accurately and efficiently. The translation of the optimized parameters obtained by 1H HR-MAS NMR in the wet laboratory provided similar results. It is proposed that 1H HR-MAS has a potential utility for optimization of various organic transformations in solid supported catalyzed reactions. Copyright
Heterocyclic reaction inducted by Br?nsted–Lewis dual acidic Hf-MOF under microwave irradiation
Nguyen, Linh Ho Thuy,Nguyen, Trang Thi Thu,Dang, Minh-Huy Dinh,Tran, Phuong Hoang,Doan, Tan Le Hoang
, (2020/11/24)
Use of green chemistry and alternative strategies has been explored to prepare diverse organic derivatives. The combination between heterogeneous catalyst, environmentally benign reaction and high-yielding methods is gaining momentum. Herein, a defective 6-connected Hf-MOF, named Hf-BTC, was efficiently synthesized and characterized for the heterogeneous catalysis under microwave irradiation. The MOF features including structural defect, porosity, acidity, and stability was analyzed by powder X-ray diffraction, N2 sorption isotherms, acid-base titration, and thermal gravimetric analysis. In the catalytic studies, the Br?nsted-Lewis dual acidic Hf-BTC was efficiently applied for the synthesis of the heterocyclic compounds via the microwave-assisted cycloaddition and condensation reactions. The reactions proceeded smoothly in the presence of the Hf-MOF with a broad scope of substrates provided the expected products in high to excellent yields (up to 99 %) for few minutes and the catalyst could be easily recycle over many consecutive reactions without loss of its reactivity and structure.
Selective synthesis of functionalized quinazolinone derivatives via biocatalysis
Gong, Bozhen,Lan, Jin,Le, Zhanggao,Li, Hongxia,Meng, Jia,Xie, Zongbo
, (2020/11/02)
A novel and efficient biocatalyzed methodology for the construction of functionalized quinazolinone derivatives via tandem / hydrolysis / decarboxylation / cyclization and transesterification reactions has been developed that works with a variety of 2-aminobenzamide and β-dicarbonyl compounds. This method requires mild conditions, and has demonstrated high catalytic activity, excellent yields, excellent chemoselectivity, and a broad substrate scope. Additionally, biocatalyzed decarboxylation does not require high temperatures or light activation, giving it a substantial advantage over alternative techniques. Most importantly, it offers a new example for the exploration of simple, convenient, and environmentally friendly synthetic routes utilizing enzymes in organic chemistry.
