7776-34-3

Basic information

• Product Name: L-Proline hydrochloride
• Synonyms: L-PROLINE HYDROCHLORIDE SOLUTION;solution100mgaminoacidin0.1mHCl;L-Proline hydrochloride;(2S)-Pyrrolidine-2-carboxylic acid·hydrochloride;(S)-pyrrolidine-2-carboxylic acid hydrochloride;L-Proline monohydrochloride
• CAS NO: 7776-34-3
• Molecular Formula: C₅H₉NO₂*ClH
• Molecular Weight: 151.59
• EINECS: 231-898-4
• Product Categories: Amino Acids, Peptides and Proteins;Amino AcidsAlphabetic;Life Sciences Standards;P;PON - PT
• Mol File: 7776-34-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 155 °C
• Boiling Point: 252.2 °C at 760 mmHg
• Flash Point: 106.3 °C
• Appearance: /
• Vapor Pressure: 0.00615mmHg at 25°C
• Storage Temp.: 2-8°C
• BRN: 5880542
• CAS DataBase Reference: L-Proline hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline hydrochloride(7776-34-3)
• EPA Substance Registry System: L-Proline hydrochloride(7776-34-3)

Safety Data

• WGK Germany: 2
• F: 10
• Hazardous Substances Data: 7776-34-3(Hazardous Substances Data)

Usage

General Description

L-Proline hydrochloride is a chemical compound that is the hydrochloride salt form of L-proline, a non-essential amino acid. It is commonly used as a pharmaceutical ingredient in the production of drugs and as a supplement in cell culture media. L-Proline is an important building block for many proteins and enzymes in the body and plays a key role in collagen formation, wound healing, and maintaining healthy skin and connective tissues. L-Proline hydrochloride is also used in the synthesis of peptides and as a chiral auxiliary in organic chemistry reactions.Overall, L-Proline hydrochloride is an important compound with diverse applications in pharmaceuticals, cell culture, and organic synthesis.

InChI:InChI=1/C5H9NO2.ClH/c7-5(8)4-2-1-3-6-4;/h4,6H,1-3H2,(H,7,8);1H/t4-;/m0./s1

Upstream product

• 1186048-83-8 desmocyclopeptide 
• 147-85-3 L-proline 
• 1314866-91-5 ethyl tumonoate A 
• 98-79-3 L-Pyroglutamic acid 
• 4931-66-2 methyl (S)-pyroglutamate 
• 212121-62-5 1-tert-butyl 5-methyl (S)-2-((diphenylmethylene)amino)pentanedioate 
• 79640-72-5 L-glutamic acid 1-tert-butyl ester 5-methyl ester 
• 2812-46-6 proline tert-butyl ester 
• 3154-58-3 N-Formyl-L-proline methyl ester 
• 2311-25-3 N-acetyl-L-proline methyl ester 
• 1334715-72-8 versicoloritide C 
• 1334715-68-2 versicoloritide B 
• 1334715-65-9 versicoloritide A 
• 85178-37-6 (S)-methyl 5-thioxopyrrolidine-2-carboxylate 

Downstream Products

• 45736-33-2 (S)-proline-N-carboxyanhydride 
• 72011-53-1 methyl (phenylthio)-L-prolinate 
• 71989-31-6 Fmoc-Pro-OH 
• 923975-40-0 C₁₃H₁₄N₄O₄ 
• 923975-42-2 C₁₃H₁₄N₄O₃ 
• 1016557-35-9 C₃₁H₃₆N₈O₁₀ 
• 1016557-34-8 C₃₀H₃₄N₈O₁₀ 
• 1016557-33-7 C₂₉H₃₂N₈O₁₀ 
• 923975-37-5 C₂₀H₂₀N₄O₅ 
• 923975-36-4 C₁₄H₁₆N₄O₅ 
• 923975-45-5 C₁₂H₁₀Br₂N₄O₃ 
• 923975-38-6 C₁₂H₁₁ClN₄O₃ 
• 166451-14-5 (2S)-1-(2-azido-benzoyl)-pyrrolidine-2-carboxylic acid 
• 1016556-93-6 C₁₉H₁₈N₄O₄ 

Relevant articles and documents

Diastereoselective hydrogenation of pyrazine derivatives: An alternative method of preparing piperazine-(2S)-carboxylic acid

The diastereoselective hydrogenation of a chiral pyrazine derivative was used for the stereoselective preparation of piperazine-2-carboxylic acid, which is an important chiral building block. The study was focused on the diastereoselective hydrogenation with various noble metal catalysts (Pd, Pt, Rh, Ru) on different supports. It was found that intramolecular cyclization of the substrate takes place during the hydrogenation, forming an unsaturated diketopiperazine derivative. This intermediate was further hydrogenated to a mixture of saturated heterocyclic diastereomers. The influence of the reaction conditions (temperature, pressure of hydrogen, and type of solvent) on the diastereoselectivity was also studied. The highest diastereoselectivity (79%) was reached with 10% Pd/C and with water as solvent. The desired molecule of piperazine-2-carboxylic acid was finally obtained by acidic hydrolysis of the diastereomeric diketopiperazine adduct.

Room temperature depolymerization of lignin using a protic and metal based ionic liquid system: an efficient method of catalytic conversion and value addition

Lignin is one of the most abundant biopolymer which can be utilized to synthesize various chemicalsviaits depolymerization. However, depolymerization of lignin generally occurs under very harsh conditions. Herein, we report the efficient depolymerization of ligninviadissolution in a mixed ionic liquid system: ethyl ammonium nitrate (EAN) + prolinium tetrachloromanganate(ii) [Pro]2[MnCl4] at 35 °C and under atmospheric pressure conditions. The high dissolution of lignin in ethyl ammonium nitrate provided a large number of H-bonding sites leading to the cracking of lignin and subsequent oxidative conversion by [Pro]2[MnCl4]viathe formation of metal-oxo bonding between Mn and lignin molecules. The extracted yield of vanillin was found to be 18-20% on lignin weight basisviaGC-MS analysis. The depolymerization of lignin was confirmed by SEM, FT-IR and PXRD analysis. Since lignin contains UV-absorbing functional groups, the regenerated biomass after the recovery of the depolymerized products was further utilized to synthesize a UV-shielding material. The constructed films from such a material exhibited a high SPF value of 22 and were found to be very effective by limiting the UV degradation of rhodamine B thus making the lignin valorization process economically viable and environmentally sustainable.

L-valine and L-proline - solid-state IR-LD spectroscopic study

Spectral investigation including IR-characteristic bands assignment of the amino acids zwitterions L-Valine (L-Val) and L-Proline (L-Pro) was carried out by linear-dichroic infrared (IR-LD) spectroscopy of oriented solid sample as a nematic liquid crystal suspension. The obtained experimental IR-LD results (transition moment directions) were compared with known crystal X-ray data for molecules orientation in the unit cells of the studied compounds, confirming the applicability of the used spectral method for structural determination. The influence of the protonation on the IR-spectroscopic patterns of the both amino acids is discussed.