77778-85-9

Basic information

• Product Name: 2-FLUORO-4'-NITROBENZOPHENONE
• Synonyms: 2-FLUORO-4'-NITROBENZOPHENONE
• CAS NO: 77778-85-9
• Molecular Formula: C₁₃H₈FNO₃
• Molecular Weight: 245.21
• Mol File: 77778-85-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 115 °C(Solv: ethanol (64-17-5))
• Boiling Point: 412.1°C at 760 mmHg
• Flash Point: 203°C
• Appearance: /
• Density: 1.335g/cm³
• Vapor Pressure: 5.32E-07mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 2-FLUORO-4'-NITROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4'-NITROBENZOPHENONE(77778-85-9)
• EPA Substance Registry System: 2-FLUORO-4'-NITROBENZOPHENONE(77778-85-9)

Safety Data

• Hazardous Substances Data: 77778-85-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H8FNO3/c14-12-4-2-1-3-11(12)13(16)9-5-7-10(8-6-9)15(17)18/h1-8H

Upstream product

• 326-62-5 2-fluorophenyl acetonitrile 
• 100-00-5 4-chlorobenzonitrile 
• 446-52-6 2-Fluorobenzaldehyde 
• 350-46-9 4-Fluoronitrobenzene 
• 1144-74-7 4-nitrobenzophenone 
• 462-06-6 fluorobenzene 
• 122-04-3 4-nitro-benzoyl chloride 

Relevant articles and documents

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.

Method for acylation or sulphonylation of an aromatic compound

The present invention relates to a process for the acylation or sulphonylation of an aromatic compound. More particularly, the invention relates to a process for the acylation or sulphonylation of an activated or deactivated aromatic compound. The invention is applied to the preparation of aromatic ketones or sulphones. The process for the acylation or sulphonylation of an aromatic compound which consists in reacting at least one aromatic compound with an acylating or sulphonylating agent, in the presence of a Friedel-Crafts catalyst is characterized in that the acylation or sulphonylation reaction is carried out in liquid phase under microwave irradiation.