778596-20-6Relevant articles and documents
Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery
Miller, Michael L.,Roller, Elizabeth E.,Zhao, Robert Y.,Leece, Barbara A.,Ab, Olga,Baloglu, Erkan,Goldmacher, Victor S.,Chari, Ravi V. J.
, p. 4802 - 4805 (2007/10/03)
To develop effective taxane-antibody immunoconjugates, we have prepared a series of modified taxanes that have both improved toxicity and solubility in aqueous systems as compared to paclitaxel (1a). These taxanes have been modified at either the C-10 or