778596-26-2 Usage
Uses
Used in Pharmaceutical Industry:
HO-PEG10-tBu is used as a solubility enhancer for improving the aqueous solubility of hydrophobic drugs. The hydrophilic PEG spacer increases the drug's interaction with water, facilitating its dissolution and absorption.
HO-PEG10-tBu is also used as a versatile building block for the synthesis of drug conjugates and prodrugs. The hydroxyl group allows for the attachment of various therapeutic agents, while the t-butyl protected carboxyl group can be deprotected to reveal a reactive carboxylic acid for further derivatization.
Used in Bioconjugation and Chemical Synthesis:
HO-PEG10-tBu serves as a valuable intermediate in the synthesis of bioconjugates, such as PEGylated proteins, peptides, and nucleic acids. The hydroxyl group provides a site for covalent attachment of these biomolecules, while the PEG spacer imparts improved stability and reduced immunogenicity.
HO-PEG10-tBu is also used in the development of self-assembling nanostructures and drug delivery systems. The PEG spacer can promote the formation of micelles, liposomes, or other nanostructures, while the hydroxyl and t-butyl protected carboxyl groups offer sites for further functionalization and targeting.
Used in Cosmetics and Personal Care Industry:
HO-PEG10-tBu is utilized as a solubilizing agent for incorporating lipophilic active ingredients into cosmetic and personal care formulations. The hydrophilic PEG spacer aids in the dispersion of these ingredients, enhancing their bioavailability and effectiveness.
HO-PEG10-tBu also serves as a stabilizer and emulsifier in cosmetic formulations, improving the stability and shelf life of emulsions and other complex mixtures. The PEG spacer can reduce interfacial tension and promote the formation of stable emulsions or dispersions.
Check Digit Verification of cas no
The CAS Registry Mumber 778596-26-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,8,5,9 and 6 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 778596-26:
(8*7)+(7*7)+(6*8)+(5*5)+(4*9)+(3*6)+(2*2)+(1*6)=242
242 % 10 = 2
So 778596-26-2 is a valid CAS Registry Number.
778596-26-2Relevant academic research and scientific papers
Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery
Miller, Michael L.,Roller, Elizabeth E.,Zhao, Robert Y.,Leece, Barbara A.,Ab, Olga,Baloglu, Erkan,Goldmacher, Victor S.,Chari, Ravi V. J.
, p. 4802 - 4805 (2007/10/03)
To develop effective taxane-antibody immunoconjugates, we have prepared a series of modified taxanes that have both improved toxicity and solubility in aqueous systems as compared to paclitaxel (1a). These taxanes have been modified at either the C-10 or
