78-75-1 Usage
Chemical Properties
1,2-Dibromopropane is considered non-flammable and non-explosive liquid.
Uses
1,2-Dibromopropane is used in organic synthesis and solvent. It was used to study the effect of reductant concentration, reductant contact time and suspension pH on reductive dechlorination of carbon tetrachloride by soil manipulated with Fe(II) and HS-. It was used as internal standard during the determination of nitrogenous disinfection byproduct trichloronitromethane by gas chromatography mass spectrometry.
Application
Photodissociation dynamics of 1,2-dibromopropane at 234 and 265 nm has been investigated by using velocity map ion imaging method. 1,2-Dibromopropane was used to study the effect of reductant concentration, reductant contact time and suspension pH on reductive dechlorination of carbon tetrachloride by soil manipulated with Fe(II) andHS-. It was used as internal standard during the determination of nitrogenous disinfection byproduct trichloronitromethane by gas chromatography mass spectrometry.
Preparation
1,2-Dibromopropane is synthesized from bromopropane by bromination. First mix bromopropane and iron powder, heat to 40-50°C, slowly add bromine, and continue to reflux for 2h after adding. Then, the iron slag was filtered off, and the filtrate was washed several times with water, once with 5% sodium carbonate solution, and then with 5% sodium thiosulfate solution to remove free bromine. Dry with anhydrous calcium chloride. Fractional distillation, collecting 139-142 ℃ fraction is the finished product of 1,2-dibromopropane.
General Description
1,2-dibromopropane is a colorless liquid. Prepared from propyl bromide and Br in the presence of AlCl3 or AlBr3. (NTP, 1992)
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Halogenated aliphatic compounds, such as 1,2-Dibromopropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. 1,2-Dibromopropane is considered nonflammable.
Fire Hazard
1,2-Dibromopropane is considered non-flammable.
Biochem/physiol Actions
1,2-Dibromopropane induces hepatotoxicity and immunotoxicity in female BALB/c mice.
Check Digit Verification of cas no
The CAS Registry Mumber 78-75-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 78-75:
(4*7)+(3*8)+(2*7)+(1*5)=71
71 % 10 = 1
So 78-75-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H6Br2/c1-3(5)2-4/h3H,2H2,1H3/t3-/m0/s1
78-75-1Relevant articles and documents
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Bodroux
, p. 241 Anm. (1901)
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Oxidative bromination of alkenes mediated with nitrite in ionic liquids
Kuznetsova, Lidia I.,Kuznetsova, Nina I.,Zudin, Vladimir N.,Utkin, Viktor A.,Trebushat, Dmitry V.,Fedotov, Martin A.,Larina, Tatyana V.
, p. 1499 - 1506,8 (2014/11/08)
The oxidative bromination of C2-C8 alkenes with HBr-NaNO2-O2 in solutions of BMImBr, HMImBr or BMImBF 4 containing 16-28 wt% H2O was studied using volumetric method, GC-MS analysis, 14N NMR and UV-VIS spectroscopy. The optimal conditions to conduct the reaction at high selectivity for 1,2-dibromoalkanes in BMImBr were determined. The composition of ionic liquid affects the catalytic performance. Although in BMImBF4 the reaction runs with equal rate as in bromide ionic liquid, the fraction of bromohydrin in the reaction products increases to 20 %. Generated from NaNO2, NOx operated as a catalyst in the oxidation of Br- and was oxidized to catalytically inert NO3 - anions when complete conversion of HBr was attained. Graphical Abstract: Oxidative bromination of alkenes [Figure not available: see fulltext.]
Rhodium-catalyzed reductive allylation of conjugated aldehydes with allyl acetate
Vasylyev, Maksym,Alper, Howard
body text, p. 2710 - 2713 (2010/07/17)
Reductive allylation of aryl and alkenyl aldehydes with allyl acetate catalyzed by the ionic diamine carbonyl rhodium complex, [Rh(TMEDA)(CO) 2][RhCl2(CO)2], under a carbon monoxide atmosphere afforded the corresponding homoallylic alcohols in good isolated yields.
