785-17-1

Basic information

• Product Name: 5,6,7,8-tetrahydro-gamma-oxonaphthalene-2-butyric acid
• Synonyms: 5,6,7,8-tetrahydro-gamma-oxonaphthalene-2-butyric acid;5,6,7,8-Tetrahydro-γ-oxo-2-naphthalenebutanoic acid;4-oxo-4-(5,6,7,8-tetrahydro-2-naphthalenyl)butanoic acid
• CAS NO: 785-17-1
• Molecular Formula: C₁₄H₁₆O₃
• Molecular Weight: 232.27504
• EINECS: 212-319-4
• Mol File: 785-17-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 464.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.188±0.06 g/cm3(Predicted)
• PKA: 4.58±0.17(Predicted)
• CAS DataBase Reference: 5,6,7,8-tetrahydro-gamma-oxonaphthalene-2-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-tetrahydro-gamma-oxonaphthalene-2-butyric acid(785-17-1)
• EPA Substance Registry System: 5,6,7,8-tetrahydro-gamma-oxonaphthalene-2-butyric acid(785-17-1)

Safety Data

• Hazardous Substances Data: 785-17-1(Hazardous Substances Data)

Upstream product

• 3360-41-6 4-phenyl-butan-1-ol 
• 64283-87-0 4-phenyl-1-iodobutane 
• 71-43-2 benzene 
• 2051-95-8 succinylbenzene 
• 1821-12-1 4-Phenylbutyric acid 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 119-64-2 tetralin 
• 4938-01-6 succinic acid monochloride 
• 5803-67-8 2-chloro-1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanone 
• 108-30-5 succinic acid anhydride 
• 7446-70-0 aluminium trichloride 
• 871893-92-4 [2-oxo-2-(5,6,7,8-tetrahydro-[2]naphthyl)-ethyl]-malonic acid 
• 108-31-6 maleic anhydride 

Downstream Products

• 129-00-0 pyrene 
• 85-01-8 phenanthrene 
• 1079-71-6 1,2,3,4,5,6,7,8-octahydroanthracene 
• 5325-97-3 1,2,3,4,5,6,7,8-Octahydrophenanthrene 
• 905590-65-0 N-(5-benzyl-4-phenyl-1,3-thiazol-2-yl)-4-oxo-4-(5,6,7,8-tetrahydronaphthalen-2-yl)butanamide 
• 782-28-5 4-(2-naphthyl)butyric acid 
• 871879-36-6 8-benzyl-1,2,3,4,5,6-hexahydro-anthracene 
• 89-32-7 Pyromellitic dianhydride 
• 1610-39-5 1,2,3,4,5,6,7,8,9,10,11,12-dodecahydrotriphenylene 
• 2141-42-6 1,2,3,4-tetrahydroanthracene 
• 476-73-3 1,2,3,4-benzenetetracaboxylic acid 
• 120-12-7 anthracene 
• 89-05-4 1,2,4,5-benzenetetracarboxylic acid 
• 613-31-0 9,10-dihydroanthracene 

Relevant articles and documents

Synthesis of asymmetrically disubstituted anthracenes

We have developed synthetic pathways toward differently substituted hydroxyanthracenes (anthrols) with the aim to investigate their photochemical reactivity in dehydration reactions. Although the syntheses of anthracenes substituted at positions 9,10 are well known, reports for the synthesis of anthracenes with different substitution patterns are scarce. Herein we review known and report novel synthetic pathways toward anthrols with substituents at 1,2-, 2,3-, and 2,6- positions. We present two synthetic approaches: (i) building of the anthracene tricyclic fused ring system from the appropriate benzene derivatives, and (ii) reduction of the corresponding anthraquinones. Reduction of 2-hydroxyanthracene-1-carbaldehyde to the corresponding alcohol yields rather unexpected 1,1′-methylenedianthracen-2-ol, whose proposed mechanism of formation is supported by experimental observations and calculations.

Synthesis of uniformly 13C-labeled polycyclic aromatic hydrocarbons

Convergent synthetic pathways were devised for efficient synthesis of a series of uniformly 13C labeled polycyclic aromatic hydrocarbons de novo from U-13C-benzene and other simple commercially-available 13C-starting compounds. All target products were obtained in excellent yields, including the alternant PAH U-13C-naphthalene, U-13C-phenanthrene, U-13C-anthracene, U- 13C-benz[a]anthracene, U-13C-pyrene and the nonalternant PAH U-13C-fluoranthene.

AMIDE COMPOUND

Disclosed is a compound represented by the formula (I) or (II) below, or a salt thereof. [In the formulae, ring A represents an optionally substituted ring (which is not a pyrrolidine, piperidine or piperazine); ring B represents an optionally substituted aromatic ring; ring D represents an optionally substituted ring; R1 and R2 independently represent a hydrogen atom or a substituent; R3 represents a hydrogen atom or a C1-6 alkyl group, or alternatively it combines with the ring A to form a non-aromatic ring; ring Aa represents an optionally substituted aromatic hydrocarbon; Y represents CH or N; Ra1 represents an optionally substituted hydrocarbon group; and Ra2 and Ra3 independently represent a hydrogen atom or a substituent.] The compound has a DGAT inhibitory effect and is useful for treatment or improvement of diseases or conditions caused by high expression or high activation of DGAT.