78316-50-4Relevant academic research and scientific papers
Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols
Xia, Anjie,Qi, Xueyu,Mao, Xin,Wu, Xiaoai,Yang, Xin,Zhang, Rong,Xiang, Zhiyu,Lian, Zhong,Chen, Yingchun,Yang, Shengyong
supporting information, (2019/05/07)
A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.
17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES
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Page/Page column 26-27, (2011/04/14)
The invention relates to 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) inhibitors, the preparation thereof and the use thereof for the treatment and prophylaxis of hormone-related, especially estrogen-related or androgen-related, diseases.
Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1)
Bey, Emmanuel,Marchais-Oberwinkler, Sandrine,Werth, Ruth,Negri, Matthias,Al-Soud, Yaseen A.,Kruchten, Patricia,Oster, Alexander,Frotscher, Martin,Birk, Barbara,Hartmann, Rolf W.
experimental part, p. 6725 - 6739 (2009/11/30)
17β-Estradiol (E2), the most potent female sex hormone, stimulates the growth of mammary tumors and endometriosis via activation of the estrogen receptor α (ERα). 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1), which is responsible for the catalytic r
Palladium-catalyzed selective 2,3-diarylation of α,α- disubstituted 3-thiophenemethanols via cleavage of C-H and C-C bonds
Nakano, Masaya,Satoh, Tetsuya,Miura, Masahiro
, p. 8309 - 8311 (2007/10/03)
α,α-Disubstituted 3-thiophenemethanols undergo selective diarylation accompanied by cleavage of the C-H and C-C bonds of the 2- and 3-positions, respectively, upon treatment with aryl bromides in the presence of a palladium catalyst to give the correspond
Synthesis of the Butanamide Derivative S 19812, a New Dual Inhibitor of Cyclooxygenase and Lipoxygenase Pathways
Tordjman, Charles,Sauveur, Frederic,Droual, Monique,Briss, Sylvie,Andre, Nathalie,Bellot, Isabelle,Deschamps, Christine,Wierzbicki, Michel
, p. 774 - 779 (2007/10/03)
The general synthetic pathway and the interactions with arachidonic acid metabolism of the new compound S 19812 (N-hydroxy-N-methyl 4-(2,3-bis-(4- methoxyphenyl)-thiophen-5-yl)butanamide, CAS 181308-68-9) were investigated. S 19812 was selected for its we
Thiophene compounds
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, (2008/06/13)
The invention relates to thiophene compounds of formula: STR1 wherein: X1, X2, Y1 and Y2, which are identical or different, each represents hydrogen or halogen, (C1 -C5)-alkyl or alkoxy, or trifluoromethyl, R1 represents hydrogen or (C1 -C5)-alkyl, A represents a straight (C1 -C5)-hydrocarbon chain of which each carbon atom is optionally mono- or di-substituted by a (C1 -C5)-alkyl, and R2 represents hydrogen, (C1 -C6)-alkyl, cyclohexyl or benzyl; and their physiologically tolerable salts. The products of the invention may be used as anti-inflammatory agents.
