78338-18-8

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 105363-16-4 N-hydroxycinnamimidoyl chloride 
• 104-55-2 3-phenyl-propenal 
• 13372-81-1 cinnamaldoxime 
• 22966-19-4 trans-4'-methoxychalcone 
• 959-23-9 4'-methoxychalcone 
• 100-52-7 benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 78324-51-3 (E)-1-(4-Methoxy-phenyl)-3-phenyl-propenone O-methyl-oxime 
• 78324-56-8 C₁₇H₁₇NO₂ 
• 3672-52-4 3-(4-methoxyphenyl)-5-phenylisoxazole 
• 148228-91-5 2-(4-methoxyphenyl)-4-phenyl-5,6,7,8-tetrahydroquinoline 
• 70265-89-3 3-(4-methoxy-phenyl)-5-phenyl-4,5-dihydro-isoxazol-4-ol 

Relevant academic research and scientific papers

An Easy Access to Oxime Ethers by Pd-Catalyzed C—O Cross-Coupling of Activated Aryl Bromides with Ketoximes and Chalcone Oximes

An efficient Pd-catalyzed method for C—O cross-coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo-chalcones has been developed. All oxime ethers were obtained in good to excellent yields by [(π-allyl)PdCl]2/tBuXPhos (L7) catalyst system. TrixiePhos (L11) was also found to be effective for the oxime coupling. This method offers an easy and smooth coupling of chalcone oximes with activated aryl bromides and bromo-chalcones, which has not been previously explored.

Stereospecific 1,4-Metallate Shift Enables Stereoconvergent Synthesis of Ketoximes

Reported herein is a stereospecific 1,4-metallate rearrangement for single-geometry ketoxime synthesis from oxime chlorides and arylboronic acids. This strategy exhibits broad substrate scope with excellent stereoselectivity under mild reaction conditions. In comparison with the conventional approaches, each configuration of unsymmetric diaryl oximes, as well as the thermodynamically less stable Z isomer of aryl alkyl ketoximes can be selectively and exclusively obtained. The reactivities of unsymmetric diaryl oximes and the Z isomer of aryl alkyl oximes, a class of underexplored molecules, enables efficient access to the corresponding isoquinolines, isoquinoline N-oxides, and amides having a single configuration.

Method for synthesizing nicotinoyl imine amide derivatives by one-pot method

The invention discloses a method for synthesizing nicotinoyl imine amide derivatives by a one-pot method in the field of organic chemical synthesis. According to the synthesis method, a copper compound is used as a catalyst, and in the presence of ligands

An improved, efficient and microwave assisted synthetic method for the synthesis of chalcone oximes: An experimental and computational study

Chalcone oximes are important molecules in organic chemistry. Extant literature contains several methods for conversion of chalcones to their oxime forms but rapid and efficient new methods need to be developed. In this study; we have investigated a new, microwave assisted synthetic method for conversion of chalcones to their oxime forms. For this purpose, a series of known chalcones were synthesized and converted to their oxime forms employing the method being examined. The results show that the proposed method is efficient, providing time and energy savings. In the second part of our study, DFT calculations with B3LYP method have been performed on the synthesized molecules and computational results have been compared with the experimentally obtained data. All DFT calculations were performed at the B3LYP/6-31G(d), B3LYP/6-311G(d, p) and B3LYP/6-311+G(2d, p) levels of theory. NMR calculations were carried out using GIAO and CSGT methods. Additionally, MEP maps, FMOs, some global reactivity descriptors and Mulliken atomic charges for the synthesized compounds were computationally determined with the same basis sets.

O-iodoxy benzoic acid–mediated synthesis of 3,5-diarylisoxazoles and isoxazole-3-carboxylic acids

A new, convenient, ecofriendly synthesis of 3,5-diarylisoxazoles is reported from a,b-unsaturated ketoximes. Similarly, a novel synthesis of isoxazole carboxylic acids is also reported. Both the methods use efficient, environmentally friendly, and nontoxic iodoxybenzoic acid (IBX) as an oxidative cyclizing reagent. Easy procedure, environmentally benign reaction conditions, and nontoxicity are advantages to the methodology.

Design, synthesis, and biological evaluation of chalcone oxime derivatives as potential immunosuppressive agents

A series of deoxybenzoin oximes were recently reported as potent immunosuppressive agents by our group. In order to continue the original research for potential immunosuppressive agents with high efficacy and low toxicity, we synthesized a series of new c