78584-30-2

Usage

Uses

Used in Material Chemistry:
Methyl 3-(3-Pyridyl)propiolate is used as a chemical intermediate for the synthesis of various materials and compounds in material chemistry. Its unique structure, containing a pyridine ring and a propiolate group, provides potential applications in the development of new materials with specific properties.
However, it is important to note that detailed information about the physical properties or specific uses of Methyl 3-(3-Pyridyl)propiolate is not widely available. Further research and development may be required to explore its full potential in various industries.

Upstream product

• 54950-20-8 methyl nicotinoylacetate 
• 1120-90-7 3-iodopyridine 
• 922-67-8 propynoic acid methyl ester 
• 2510-23-8 3-Ethynylpyridine 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 
• 80673-00-3 3-[(trimethylsilyl)ethynyl]pyridine 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 59-67-6 nicotinic acid 
• 78584-31-3 3-Oxo-3-pyridin-3-yl-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid methyl ester 
• 186581-53-3 diazomethane 
• 59608-01-4 3-(pyridin-3-yl)propiolic acid 

Downstream Products

• 1126-73-4 (E)-3-(pyridin-3-yl)acrylamide 
• 59608-01-4 3-(pyridin-3-yl)propiolic acid 

Relevant academic research and scientific papers

Catalytic, transition-metal-free semireduction of propiolamide derivatives: Scope and mechanistic investigation

We report a transition-metal-free trans-selective semireduction of alkynes with pinacolborane and catalytic potassium tert-butoxide. A variety of 3-substituted primary and secondary propiolamides, including an analog of FK866, a potent nicotinamide mononucleotide adenyltransferase (NMNAT) inhibitor, are reduced to the corresponding (E)-3-substituted acrylamide derivatives in up to 99% yield with >99:1 E/Z selectivity. Mechanistic studies suggest that an activated Lewis acid-base complex transfers a hydride to the α-carbon followed by rapid protonation in a trans fashion.

CsF-promoted carboxylation of aryl(hetaryl) terminal alkynes with atmospheric CO2 at room temperature

A CsF-promoted carboxylation of aryl(hetaryl) terminal alkynes with atmospheric CO2 in the presence of trimethylsilylacetylene was developed to give functionalized propiolic acid products at room temperature. A wide range of propiolic acids bearing functional groups was successfully obtained in good to excellent yields. Mechanistic studies demonstrate that in the carboxylation process the alkynylsilane intermediate was first in situ generated, which was then trapped by CO2, giving rise to the corresponding functionalized propiolic acids after acidification. The advantages of this approach include avoiding use of transition-metal catalysts, wide substrate scope together with excellent functional group tolerance, ambient conditions and a facile work-up procedure.

Carboxylation of alkynylsilanes with carbon dioxide mediated by cesium fluoride in DMSO

The facile syntheses of a variety functionalized propiolic acids were achieved by carboxylation of alkynylsilanes with carbon dioxide mediated by cesium fluoride under ambient conditions. This journal is The Royal Society of Chemistry 2013.

Substituted indoles and their use as integrin antagonists

The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.