78774-31-9

Upstream product

• 107-06-2 1,2-dichloro-ethane 
• 100-46-9 benzylamine 
• 100-39-0 benzyl bromide 
• 140-28-3 N,N'-Dibenzylethylenediamine 
• 104-71-2 N,N'-bis(benzyliden)ethylendiamine 
• 107-15-3 ethylenediamine 
• 100-51-6 benzyl alcohol 
• 100-52-7 benzaldehyde 

Downstream Products

• 154780-22-0 (S)-<1,2-(N-benzyl-N,N-diibenzyl)diaminoethane>-N^α-(benzyloxycarbonyl)prolinamide 
• 1027846-35-0 (S)-Pyrrolidine-2-carboxylic acid benzyl-(2-dibenzylamino-ethyl)-amide 

Relevant academic research and scientific papers

METHOD FOR PRODUCING N-MONOALKYL-SUBSTITUTED ALKYLENE AMINE

PROBLEM TO BE SOLVED: To provide a method for producing an N-monoalkyl-substituted alkylene amine especially useful for uses such as medicine intermediates, agrochemical intermediates, urethane resin-foaming catalysts, surfactants and the like among alkyl-substituted alkylene amine compounds from an alcohol and an alkylene amine as raw materials. SOLUTION: This method for producing the N-monoalkyl-substituted alkylene amine is characterized by reacting the alkylene amine with a ≥2C alkyl alcohol in the presence of a copper-containing oxide catalyst system. The N-monoalkyl-substituted alkylenamine is produced in high conversion and in N-monoalkylation selectivity.

Homochiral lithium amides: Enantioselective deprotonation of cyclohexene oxide

Reaction of cyclohexene oxide with chiral lithium amides has been studied and (S)-2-cyclohexen-1-ol was prepared in 20-82% ee. The optical purity was determined by proton NMR measurement of α-methoxy-α- (trifluoromethyl)phenylacetic acid (MTPA) derivative of the corresponding alcohol.