79356-61-9

Upstream product

• 62515-35-9 (1SR,5RS,6RS,7RS)-6-<4-(3-chlorophenoxy)-3-oxobut-1(E)-en-1-yl>-7-trimethylsiloxy-2-oxabicyclo<3.3.0>octan-3-one 
• 40665-94-9 dimethyl 3-(3-chlorophenoxy)-2-oxopropylphosphonate 
• 123989-25-3 (1SR,2RS,6SR,8RS)-10-(3-chlorophenoxymethyl)-10,12-dimethoxy-5,9-dioxatricyclo<6.4.0.0^2,6>dodecan-4-one 

Downstream Products

• 130184-37-1 (3aα,3bβ,6R*,7aα,8aα)-4-(4-(3-chlorophenoxy)-3-oxobutyl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one 
• 52267-81-9 <3aα,4α,5β,6aα>-(+/-)-hexahydro-5-hydroxy-4-<(E)-4-(3-chlorophenoxy)-(3α)-hydroxy-1-butenyl>-2H-cyclopentafuran-2-one 
• 40665-92-7 cloprostenol 
• 40665-92-7 16-(m-chlorophenoxy)-9α,11α,15β-trihydroxy-17,18,19,20-tetranor-5-cis-13-trans-prostadienoic acid 

Relevant academic research and scientific papers

Intramolecular Acetalization of 5-Hydroxy Ketones and Enones. A Novel Transformation of Important Prostaglandin Intermediates under Acidic Conditions

Intermediates in the synthesis of ω-tetranor 16-aryloxy prostaglandins, which are 5-hydroxy enones undergo quantitative intramolecular transformation into cyclic methyl acetals in acidic methanolic solution.The reaction proceeds via the corresponding 5-hydroxy-3-methoxy ketones, which partly exist as hemiacetals.The structure of the compounds investigated was elucidated by 1H NMR spectroscopy and by X-ray analysis of the acetal (11).

PROSTANOIDS. XIX. THE SYNTHESIS OF 14C-LABELED CLOPROSTENOL

A 1:3400 mixture of 2-14C-labelled methyl bromoacetate with the nonradioactive ester gave labelled dimethoxy-2-oxo-3-(m-chlorophenoxy)phosphonate which was used for the synthesis of 16-14C-labelled cloprostenol by the Corey strategy.