794-05-8

Basic information

• Product Name: 1,2-diphenyl-2-(piperidin-1-yl)ethanone
• Synonyms: 1,2-Diphenyl-2-(piperidin-1-yl)ethanone; 1,2-Diphenyl-2-piperidin-1-yl-ethanone; ethanone, 1,2-diphenyl-2-(1-piperidinyl)-
• CAS NO: 794-05-8
• Molecular Formula: C₁₉H₂₁NO
• Molecular Weight: 279.3761
• Mol File: 794-05-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 82-84 °C(Solv: ethanol, 80% 3N (64-17-5))
• Boiling Point: 409.3°C at 760 mmHg
• Flash Point: 149.8°C
• Density: 1.106g/cm³
• Vapor Pressure: 6.56E-07mmHg at 25°C
• Refractive Index: 1.591
• PKA: 6.82±0.10(Predicted)
• CAS DataBase Reference: 1,2-diphenyl-2-(piperidin-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-diphenyl-2-(piperidin-1-yl)ethanone(794-05-8)
• EPA Substance Registry System: 1,2-diphenyl-2-(piperidin-1-yl)ethanone(794-05-8)

Safety Data

• Hazardous Substances Data: 794-05-8(Hazardous Substances Data)

Usage

Synonym

D2PE

Type of compound

Ketone

Structural feature

Piperidine ring attached to the second carbon atom

Classification

Aromatic compound

Applications

a. Building block for pharmaceuticals
b. Building block for agrochemicals
c. Building block for other fine chemicals
d. Key intermediate in drug production
e. Used in flavors and fragrances production

Physical appearance

White to light yellow crystalline solid

Odor

Characteristic odor

Stability

Stable under normal conditions

Safety precautions

a. Can cause skin irritation
b. Can cause eye irritation
c. Can cause respiratory system irritation
d. Handle with care to avoid exposure

Upstream product

• 110-89-4 piperidine 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 447-31-4 Desyl chloride 
• 1484-50-0 desyl bromide 
• 2156-71-0 N-chloropiperidine 
• 451-40-1 phenyl benzyl ketone 
• 141-52-6 sodium ethanolate 
• 100-52-7 benzaldehyde 

Downstream Products

• 27590-64-3 1,1,2-triphenyl-2-piperidin-1-yl-ethanol 
• 17244-78-9 rac-1,2-diphenyl-2-(piperidin-1-yl)ethan-1-ol 
• 17244-78-9 erythro-2-piperidino-1,2-diphenylethanol 
• 78792-49-1 1,2-diphenyl-2-(piperidin-1-yl)ethanol 
• 17243-73-1 ((RS,SR)-α'-hydroxy-bibenzyl-α-yl)-1-methyl-piperidinium; iodide 

Relevant articles and documents

Further evidences about the role of bis(thiazolin-2-ylidene)s as the actual catalytic species in the generalised benzoin condensation

Applying our mechanistic hypothesis about the real catalytic species in the benzoin condensation catalysed by thiazosium salts plus bases, we have succeed in the extension to aldehydes different from formaldehyde of a previously described method of synthe

Unusual redox behavior in the photoinduced electron-transfer reactions of amino ketones

Irradiation of a wet benzene solution of 1,2-diphenyl-2-piperidino-l-ethanone and 9,10-dicyanoanthracene leads to the formation of benzil and deoxybenzoin. We have interpreted these products as arising from deprotonation leading to net oxidation coupled with reductive elimination. The latter pathway is noteworthy in that we show reductive elimination of an electron donor can be a chief consequence of photochemical single electron transfer (SET) quenching.

Preparation of amino alcohols and diamines having a phenylethylamine structure

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