79413-86-8Relevant academic research and scientific papers
Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C-H Amidation
Jung, Hoi-Yun,Chang, Sukbok,Hong, Sungwoo
supporting information, p. 7099 - 7103 (2019/09/07)
A new approach has elaborated on the conversion of γ-lactones to the corresponding NH γ-lactams that can serve as γ-lactone bioisosteres. This approach consists of reductive C-O cleavage and an Ir-catalyzed C-H amidation, offering a powerful synthetic tool for accessing a wide range of valuable NH γ-lactam building blocks starting from γ-lactones. The synthetic utility was further demonstrated by the late-stage transformation of complex bioactive molecules and the asymmetric transformation.
Lithiierung in α-Stellung zum N-Atom von Triphenylacetamiden aus cyclischen sekundaeren Aminen. Umlagerung metallierter Triphenylacetamide unter 1,3-Verschiebung der Carbamoylgruppe
Wykypiel, Werner,Lohmann, Jean-Jaques,Seebach, Dieter
, p. 1337 - 1346 (2007/10/02)
The reagents 2 - generally available by lithiation of the triphenylacetamides 1 - react with non-enolizable carbonyl compounds and benzyl halide (s.Tables 1 and 2, and products 3).The limits of thermal stability of metalated triphenylacetamides above 0 de
