79447-11-3

Upstream product

• 92-52-4 biphenyl 
• 100-07-2 4-methoxy-benzoyl chloride 
• 5122-94-1 4-biphenylboronic acid 
• 29913-00-6 (diethyl phosphoric) 4-methoxybenzoic anhydride 
• 142957-94-6 4-(4-methoxybenzyl)-1,1'-biphenyl 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 100-66-3 methoxybenzene 
• 78322-97-1 phenyl [1,1′-biphenyl]-4-carboxylate 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 90986-71-3 4-(1-(4-methoxyphenyl)vinyl)-1,1'-biphenyl 
• 79446-97-2 3-Biphenyl-4-yl-3-hydroxy-3-(4-methoxy-phenyl)-propionic acid ethyl ester 
• 100-09-4 4-methoxybenzoic acid 
• 92-92-2 biphenyl-4-carboxylic acid 
• 79446-96-1 (R)-3-Biphenyl-4-yl-3-hydroxy-3-(4-methoxy-phenyl)-propionic acid 
• 3558-83-6 [1,1'-biphenyl]-4-yl(4-hydroxyphenyl)methanone 

Relevant academic research and scientific papers

The second aryl ketone compounds

The invention provides a synthetic method for diaryl ketone compounds. The method comprises the following steps: adding ester derivatives of raw material diaryl methanol, DDQ and water into an organic solvent, carrying out stirring, then carrying out heating to 110 to 140 DEG C and carrying out reaction for 0.5 to 12 h, and subjecting obtained reaction liquid to after-treatment so as to obtain the diaryl ketone compounds, wherein the ester derivatives of the raw material diaryl methanol have a structural formula as shown in a formula (V), (VI), (VII) or (VIII), and one-to-one correspondingly obtained products have the structural formula as shown in the formula (I), (II), (III) or (IV). The synthetic method for the diaryl ketone compounds provided by the invention has the advantages of simple, convenient and safe operation, mild reaction conditions and high product selectivity.

Palladium-catalyzed Suzuki-Miyaura coupling of aryl esters

The Suzuki-Miyaura coupling is among the most important C-C bond-forming reactions available due to its reliability, chemoselectivity, and diversity. Aryl halides and pseudohalides such as iodides, bromides, and triflates are traditionally used as the electrophilic coupling partner. The expansion of the reaction scope to nontraditional electrophiles is an ongoing challenge to enable an even greater number of useful products to be made from simple starting materials. Herein, we present how an NHC-based Pd catalyst can enable Suzuki-Miyaura coupling where the C(acyl)-0 bond of aryl esters takes on the role of electrophile, allowing the synthesis of various ketone-containing products. This contrasts known reactions of similar esters that provide biaryls via nickel catalysis. The underlying cause of this mechanistic divergence is investigated by DFT calculations, and the robustness of esters compared to more electrophilic acylative coupling partners is analyzed.

Diaryl a ketone compound catalytic oxidation synthesis method

The invention provides a catalytic oxidation synthesis method of a diaryl ketone compound. In an organic solvent, ester derivatives of diaryl methanol are used as reaction substrates, DDQ and TBN are used as catalysts, oxygen is used as an oxidant, so as to react for 1 to 12 h under the conditions of oxygen pressure of 0.1 to 0.4 MPa and temperature of 110 to 140 DEG C, and post processing is performed on reaction liquid, so as to obtain a product of the diaryl ketone compound; structural formulas of the ester derivatives of the diaryl methanol as the reaction substrates are shown in the formulas (V), (VI), (VII) or (VIII), and structural formulas of products which are correspondingly obtained one by one are shown in the formulas (I), (II), (III) or (IV). The catalytic oxidation synthesis method has the advantages of simplicity, convenience and safety in operation, mild reaction condition, high product selectivity and environmental friendliness.

DDQ/tert-Butyl nitrite-catalyzed aerobic oxidation of diarylmethane sp3 C-H bonds

An efficient 2,3-dichloro-5,6-dicyano-1,4-benzoquinone/tert-butyl nitrite-catalyzed aerobic oxidation of diarylmethane sp3 C-H bonds in the presence of acetic acid has been developed. Under the optimal reaction conditions, a number of diarylmethanes can be directly converted to their corresponding diarylketones in good to excellent yields. In addition, a plausible reaction mechanism has been investigated.

Carboxylic phosphoric anhydrides as a new coupling partner in Pd-catalyzed coupling reactions: A new ketone synthesis

The Pd-catalyzed cross-coupling reactions of carboxylic phosphoric anhydrides with organoboronic acids or organostannanes afforded the corresponding ketones. The intramolecular Heck reaction was successful with carboxylic phosphoric anhydrides as a coupling partner. Georg Thieme Verlag Stuttgart.

Synthesis and structure-activity relationship for new series of 4-phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase

We discovered a new series of 4-phenoxyquinoline derivatives as potent and selective inhibitors of the platelet-derived growth factor receptor (PDGFr) tyrosine kinase. We researched the highly potent and selective inhibitors on the basis of both PDGFr and epidermal growth factor receptor (EGFr) inhibitory activity. First, we found a compound, Ki6783 (1), which inhibited PDGFr autophosphorylation at 0.13 μM, but it did not inhibit EGFr autophosphorylation at 100 μM. After extensive explorations, we found the two desired compounds, Ki6896 (2) and Ki6945 (3), which are substituted by benzoyl and benzamide at the 4-position of the phenoxy group on 4-phenoxyquinoline, respectively. These inhibitory activities were 0.31 and 0.050 μM, respectively, but neither of them inhibited EGFr autophosphorylation at 100 μM. We further investigated the profile of both compounds toward various tyrosine and serine/threonine kinases. The three compounds specifically inhibited PDGFr rather than the other kinases.

Synthesis and structure-activity relationships of benzophenone hydrazone derivatives with insecticidal activity

A broad range of benzophenone hydrazone derivatives was prepared and tested against selected chewing insect pests, allowing the analysis of structure-activity relationships. Good activity was found only when the aromatic rings were substituted at the 4-positions with an halogen atom and a triflate or perhaloalkoxy group. In contrast, a number of substituents on the hydrazone part led to active compounds, the best results being achieved with acyl-type substituents. The excellent laboratory and greenhouse activity of the best representatives was confirmed in semi-field trials against Spodoptera littoralis. ° 2001 Society of Chemical Industry.

Syntheses of Asymmetrical Diaryl and Aryl Alkyl Ketones as Possible Non-steroidal Antiprogestational Agents

A number of asymmetrical diaryl and aryl alkyl ketones have been synthesised as possible non-steroidal antiprogestational agents.Evaluation of these compounds as competitive inhibitors of progesterone binding to uterine cytosol progesterone receptors of rabbit and human indicates that 3-methyl-4'-phenylbenzophenone (2) exhibits marginal activity in both the cases.However, this compound has been found to be inferior to R 5020 and d-norgestrel.

Friedel-Crafts Aroylation of Benzene and Biphenyl in Methylene Chloride

Reactions of acid chlorides of o-, m- and p-toluic acids, p-methoxy- and 3,4-methylenedioxybenzoic acids with biphenyl in the presence of anhydrous AlCl3 in methylene chloride have been studied.Of these, only the reactions of o-, m- and p-toluoly chlorides with biphenyl indicates inter- and intramolecular methylene insertions in the reaction products.It is observed that the 2-, 3- and 4-methylbenzophenones, formed as intermediates, participate in the methylene insertion reactions.In a few cases, besides methylene insertion, methyl insertion has also occurred.Unlike these reactions, the reaction of o-toluoyl chloride with benzene in presence of anhydrous AlCl3 in methylene chloride gives 2-methyl-3-(p-benzylphenyl)benzophenone.The structural assignment of these products are made on the basis of their PMR and mass spectra.