79947-88-9

Basic information

• Product Name: methyl 4-trifluoromethylcinnamate
• Synonyms: methyl 4-trifluoromethylcinnamate
• CAS NO: 79947-88-9
• Molecular Weight: 230.186
• Mol File: 79947-88-9.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: methyl 4-trifluoromethylcinnamate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-trifluoromethylcinnamate(79947-88-9)
• EPA Substance Registry System: methyl 4-trifluoromethylcinnamate(79947-88-9)

Safety Data

• Hazardous Substances Data: 79947-88-9(Hazardous Substances Data)

Upstream product

• 16642-92-5 4-(trifluoromethyl)cinnamic acid 
• 67-48-1 choline chloride 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 292638-85-8 acrylic acid methyl ester 
• 98-56-6 4-chlorobenzotrifluoride 
• 67-56-1 methanol 
• 74-88-4 methyl iodide 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 20754-22-7 methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate 
• 88738-78-7 bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate 
• 98-08-8 α,α,α-trifluorotoluene 
• 79-20-9 acetic acid methyl ester 
• 120681-07-4 3-(4-trifluoromethyl-phenyl)-acryloyl chloride 

Downstream Products

• 125617-18-7 3-(4-trifluoromethylphenyl)-2-propen-1-ol 
• 849442-21-3 methyl 3-(4-(trifluoromethyl)phenyl)propanoate 
• 103977-75-9 p-trifluoromethyl cinnamyl chloride 
• 205108-18-5 (E)-1-(buta-1,3-dien-1-yl)-4-(trifluoromethyl)benzene 
• 95123-61-8 4-(trifluoromethyl)cinnamaldehyde 

Relevant articles and documents

Photoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites

The Fujiwara-Moritani reaction has had a profound contribution in the emergence of contemporary C-H activation protocols. Despite the applicability of the traditional approach in different fields, the associated reactivity and regioselectivity issues had

Synthesis and discovery of 18β-glycyrrhetinic acid derivatives inhibiting cancer stem cell properties in ovarian cancer cells

Despite advances in ovarian cancer treatment, the five-year overall survival rate is less than 30% with the presence of cancer stem cells (CSCs). To develop CSC-targeting therapy, a series of 18β-glycyrrhetinic acid (GA) derivatives containing cinnamamide moiety have been designed, synthesized, and screened for their antiproliferative activity in SKOV3 and OVCAR3 cells. Most of the compounds exhibited stronger antiproliferative activity than GA, and compound 7c was the most active one. Further biological studies showed that compound 7c could induce apoptosis and suppress migration. In addition, compound 7c could not only observably decrease the colony formation and sphere formation ability, but also significantly reduce the CD44+, CD133+, and ALDH+ subpopulation in SKOV3 and OVCAR3 cells. In conclusion, these results indicate that compound 7c is a promising anti-CSC agent for further anti-ovarian cancer studies.

Selective Palladium-Catalyzed Carbonylation of Alkynes: An Atom-Economic Synthesis of 1,4-Dicarboxylic Acid Diesters

A class of novel diphosphine ligands bearing pyridine substituents was designed and synthesized for the first time. The resulting palladium complexes of L1 allow for chemo- and regioselective dialkoxycarbonylation of various aromatic and aliphatic alkynes affording a wide range of 1,4-dicarboxylic acid diesters in high yields and selectivities. Kinetic studies suggest the generation of 1,4-dicarboxylic acid diesters via cascade hydroesterification of the corresponding alkynes. Based on these investigations, the chemo- and regioselectivities of alkyne carbonylations can be controlled as shown by switching the ligand from L1 to L3 or L9 to give α,β-unsaturated esters.