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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-Methyl-3-nitroquinoline is utilized as a crucial intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows it to serve as a building block for the development of new drugs and agricultural products, contributing to advancements in these fields.
Used in Research and Development:
As a fluorescent probe, 4-Methyl-3-nitroquinoline is employed in the detection of metal ions. This application is particularly valuable in research settings, where the identification and analysis of metal ions are essential for understanding chemical reactions and developing new technologies.
Used in Environmental and Health Impact Studies:
Due to its mutagenic and cytotoxic effects, 4-Methyl-3-nitroquinoline is the subject of research aimed at understanding its potential health and environmental impacts. This research is vital for assessing the risks associated with the compound and informing the development of safety guidelines and regulations.

InChI:InChI=1/C10H8N2O2/c1-7-8-4-2-3-5-9(8)11-6-10(7)12(13)14/h2-6H,1H3

Upstream product

• 10501-54-9 2-(2-nitroethylideneamino)acetophenone 
• 39061-97-7 4-chloro-3-nitroquinoline 
• 105-53-3 diethyl malonate 
• 17576-53-3 3-nitroquinoline 
• 3112-85-4 methylphenylsulfonate 
• 580-17-6 3-aminoquinoline 
• 7647-01-0 hydrogenchloride 
• 5653-21-4 metazonic acid 
• 551-93-9 2-aminoacetophenone 
• 7732-18-5 water 

Downstream Products

• 411211-45-5 [1,2,3]triazino[4,5-c]quinoline-2-oxide 
• 1421349-23-6 C₂₂H₂₄N₂O₂ 
• 1421349-24-7 C₂₆H₃₁N₃O₃ 
• 1421348-72-2 ethyl 4-(3-methyl-1-(4-methylquinolin-3-ylamino)butyl)benzoate 
• 1421348-44-8 C₂₅H₂₉N₃O₃ 

Relevant academic research and scientific papers

Alkylation of Nitropyridines via Vicarious Nucleophilic Substitution

Electrophilic nitropyridines react with sulfonyl-stabilized carbanions to give products of C-H alkylation via vicarious nucleophilic substitution. The process consists of formation of the Meisenheimer-type adduct followed by base-induced β-elimination of the sulfinic acid (e.g., PhSO2H). Mechanistic studies reveal that in the latter step alkyl substituent and adjacent nitro group tend to planarize for effective stabilization of benzyl anion, and thus, adduct of hindered isopropyl carbanion remains stable toward elimination for steric reasons.

SYNTHESIS OF INDOLES FROM PYRIDINIUM SALTS. 6. REACTION OF 3-NITROQUINOLINIUM SALTS WITH KETONES IN THE PRESENCE OF AMINES

It is shown that in the reaction of 3-nitroquinolinium salts with aliphatic ketones and amines the ketone adds to the 2 and 4 positions with the formation of tricyclic adducts - benzazabicyclononane derivatives.Their conformational analysis was carried ou

Naphthyridines. IV. Synthesis of Benzo-1,7-naphthyridines

Benzo-1,7-naphthyridines have been synthesized from 3-nitrolepidine (3) by a sequence involving monobromination of the methyl group of 3, oxidation of the bromomethyl group to the carboxyaldehyde group by Franzen's trimethylamine N-oxide procedure, and