79965-71-2Relevant academic research and scientific papers
PdII-Catalyzed Regio- and Enantioselective Oxidative C?H/C?H Cross-Coupling Reaction between Ferrocenes and Azoles
Cai, Zhong-Jian,Liu, Chen-Xu,Gu, Qing,Zheng, Chao,You, Shu-Li
supporting information, p. 2149 - 2153 (2019/01/24)
Asymmetric C?H bond functionalization reaction is one of the most efficient and straightforward methods for the synthesis of optically active molecules. Herein we disclose an asymmetric C?H/C?H cross-coupling reaction of ferrocenes with azoles such as oxazoles and thiazoles. Palladium(II)/monoprotected amino acid (MPAA) catalytic system which exhibits excellent reactivity and regioselectivity for oxazoles and thiazoles. This method offers a powerful strategy for constructing planar chiral ferrocenes. Mechanistic studies suggest that the C?H bond cleavage of azoles is likely proceeding through a SEAr process and may not be a turnover limiting step.
Hypervalent iodane mediated reactions of: N -acetyl enamines for the synthesis of oxazoles and imidazoles
Xu, Kang,Yang, Ruiqi,Yang, Shuang,Jiang, Cheng,Ding, Zhenhua
supporting information, p. 8977 - 8981 (2019/10/28)
A hypervalent iodane reagent used for the intramolecular cyclization of N-acetyl enamines and intermolecular cyclocondensation of enamines and nitriles was investigated. The reaction was performed under mild conditions and gave oxazoles and imidazoles, respectively, in moderate to excellent yields. This transformation exhibits good reactivity, selectivity and functional group tolerance. The selectivity of the intra- or intermolecular reaction is dependent on the structure of N-acetyl enamines.
Copper-catalyzed direct synthesis of iodoenamides from ketoximes
Liang, Hao,Ren, Zhi-Hui,Wang, Yao-Yu,Guan, Zheng-Hui
, p. 9789 - 9794 (2013/08/23)
Iodide in copper's pathway: A new, efficient, and practical copper-catalyzed synthesis of Z-iodoenamides from readily available ketoximes has been developed (see scheme). The reaction was believed to proceed through a single-electron-transfer pathway. The corresponding Z-iodoenamides have been applied to the synthesis of substituted oxazoles, dienes, β-phenoxyl enamides, eneynes, β-acylenamides, and pyrroles (DCE=1,2-dichloroethane). Copyright
Synthesis of some New Fluorine containing Oxazoles, Oxadiazoles, Thiadiazoles and Triazines
Pathak, Vijai N.,Goyal, Mahendra K.,Jain, Meenakshi,Joshi, Krishna C.
, p. 539 - 542 (2007/10/02)
Treatment of fluorine containing phenacyl bromides with urea or substituted arylureas afforded the corresponding 2-(amino/N-arylamino)-4-(fluoroaryl)oxazoles, and with ammonium acetate in glacial acetic acid yielded 2-methyl-4-(fluoroaryl)oxazoles.Fluorin
