80336-72-7

Basic information

• Product Name: 2-IODO-1-(4-METHOXY-PHENYL)-ETHANONE
• Synonyms: 2-IODO-1-(4-METHOXY-PHENYL)-ETHANONE
• CAS NO: 80336-72-7
• Molecular Formula: C₉H₉IO₂
• Molecular Weight: 276.07103
• Mol File: 80336-72-7.mol
• Article Data: 59

Chemical Properties

• Melting Point: 61°C
• Boiling Point: 346°Cat760mmHg
• Flash Point: 163°C
• Appearance: /
• Density: 1.685g/cm³
• Vapor Pressure: 5.94E-05mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-IODO-1-(4-METHOXY-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODO-1-(4-METHOXY-PHENYL)-ETHANONE(80336-72-7)
• EPA Substance Registry System: 2-IODO-1-(4-METHOXY-PHENYL)-ETHANONE(80336-72-7)

Safety Data

• Hazardous Substances Data: 80336-72-7(Hazardous Substances Data)

Usage

Preparation

To a solution of 4-methoxyacetophenone (2 mmol) in methanol, containing iodine (1 mmol) and a 30% aqueous solution of hydrogen peroxide (1.2 mmol), was added concentrated sulfuric acid (0.2 mmol) and the mixture stirred at 60° for 1–3 h (94%) To a solution of 4-methoxyacetophenone (1 mmol) in methanol, containing iodine (0.5 mmol) and a 30% aqueous solution of hydrogen peroxide (0.6 mmol), was added H4SiO4.12WO3 (0.03–0.033 mmol) and the mixture stirred at 65° for 1.5–3 h (95%) Also obtained by reaction of iodine with 4-methoxyacetophenone in the pres-ence of cupric oxide in methanol at 65° for 1 h (99%). Also obtained by reaction of potassium iodide with w-chloro-p-methoxyacetophenone by prolonged heating in aqueous alcohol or in nitromethane.

InChI:InChI=1/C9H9IO2/c1-12-8-4-2-7(3-5-8)9(11)6-10/h2-5H,6H2,1H3

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 67-56-1 methanol 
• 768-60-5 4-methoxyphenylacetylen 
• 1515-95-3 p-ethylanisole 
• 61926-37-2 1-(iodoethynyl)-4-methoxybenzene 
• 637-69-4 4-Methoxystyrene 
• 80336-71-6 2-iodo-1,1-dimethoxy-1-(4-methoxyphenyl)ethane 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 41068-36-4 2-chloro-4-methoxyacetophenone 

Downstream Products

• 4136-21-4 p-methoxybenzoylmethanol 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1076-95-5 p-methoxyphenylglyoxal 
• 895570-48-6 (Z)-1,4-bis(4-methoxyphenyl)-2-(methylthio)but-2-ene-1,4-dione 
• 220526-76-1 (5-chlorobenzofuran-2-yl)(4-methoxyphenyl)methanone 
• 32816-75-4 (5-bromobenzofuran-2-yl)(4-methoxyphenyl)methanone 
• 1220125-52-9 ethyl 2-benzoyl-4-(4-methoxyphenyl)-4-oxobut-2-enoate 
• 1198087-71-6 1-(4-methoxyphenyl)-2-(5-methyl-2-furyl)-1-ethanone 
• 1350624-42-8 C₁₀H₁₀O₃⁽¹⁸⁾O 
• 171119-05-4 2-Oxo-2-(4-methoxyphenyl)ethyl formate 
• 33429-12-8 benzothiazol-2-yl-(4-methoxyphenyl)methanone 
• 1394973-47-7 (5-chlorobenzo[d]thiazol-2-yl)(4-methoxyphenyl)methanone 
• 1436865-48-3 3-(4-methoxybenzoyl)indolizine-1-carbonitrile 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

Enolization versus carbonylation at glassy carbon surface through cathodic means

The cathodic reduction of ω-bromomethylarylketones in aprotic organic solvents (such as propylene carbonate) containing tetraalkylammonium iodides achieved at smooth glassy carbon (GC) permits through a selective one-electron reduction, the scission of th

Au(I)-Catalyzed Hydration of 1-Iodoalkynes Leading to α-Iodoketones

A catalytic protocol for the Au(I)-catalyzed hydration of 1-iodoalkynes is disclosed. The use of Au(I)–NHC catalyst enabled the straightforward synthesis of a variety of α-iodomethyl ketones in good to excellent yields. The utility of this simple method is further highlighted by showcasing iodination/hydration and hydration/oxidation sequential protocols leading to the construction of molecular complexity.

Metal-Free, Oxidant-Free, and Controllable Graphene Oxide Catalyzed Direct Iodination of Arenes and Ketones

A direct, metal-free, and oxidant-free method for the graphene oxide (GO)-catalyzed iodination of arenes and ketones with iodine in a neutral medium was explored. This iodination protocol was performed by using a simple technique to avoid the use of external metal catalysts and oxidants and harsh acidic/basic reaction conditions. In addition, by this method the degree of iodination could be controlled, and the reaction was scalable and compatible with air. This strategy opens a new field for GO-catalyzed chemistry and provides an avenue for the convenient direct iodination of arenes and ketones.