80550-48-7

Upstream product

• 82463-72-7 2-bromo-4,5-dimethoxy-N-methylbenzenemethanamine 
• 67-64-1 acetone 
• 5653-42-9 3,4-dimethoxyhomophthalic anhydride 
• 75-36-5 acetyl chloride 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

Studies on SRN1 Reactions. Part 6: Synthesis of 3-Methyl Derivatives of the Alkaloids Thalactamine, Doryanine, and 6,7-Dimethoxy-N-methyl-1(2H)-isoquinolone

A new, short synthesis of the 3-methyl derivatives (3a-c) of the alkaloids thalactamine, doryanine, and 6,7-dimethoxy-N-methyl-1(2H)-isoquinolone, based upon our previous SRN1 synthesis of isocarbostryril systems, is reported.

Synthesis of 6,7-Dimethoxyisoquinolones and of 6,7-Dimethoxy-2-methyl-1(2H)-isoquinolone, an Alkaloid of Hernandia ovigera

3-Methyl, 3-formyl, 3-carboxy- and 3-hydroxymethyl-6,7-dimethoxy-1(2H)-isoquinolones (Ia-IVa) and their N-methyl (Ib-IVb) derivatives have been synthesized starting from 6,7-dimethoxyhomophthalic acid.Decarboxylation of 3-carboxyisoquinolones furnishes the corresponding isoquinolones and thus provide a new synthesis for the natural alkaloid, 6,7-dimethoxy-2-methyl-1(2H)-isoquinolone (Vb). β-- and 6β--acrylic acvids (VIa,b) have also been synthesized.