80741-40-8Relevant academic research and scientific papers
Catalytic Generation of Rhodium Silylenoid for Alkene-Alkyne-Silylene [2 + 2 + 1] Cycloaddition
Ohmura, Toshimichi,Sasaki, Ikuo,Suginome, Michinori
supporting information, p. 1649 - 1653 (2019/03/20)
An alkene-alkyne-silylene [2 + 2 + 1] cycloaddition takes place in the rhodium-catalyzed reaction of 1,6-enynes with borylsilanes bearing an alkoxy group on the silicon atoms, which react as synthetic equivalents of silylene. The reaction proceeds efficiently in 1,2-dichloroethane at 80-110 °C in the presence of a rhodium catalyst bearing bis(diphenylphosphino)methane (DPPM) as a ligand to afford 1-silacyclopent-2-enes in good to high yields.
Lewis acidic FeCl3 promoted 2-aza-Cope rearrangement to afford α-substituted homoallylamines in dimethyl carbonate
Gadde, Karthik,Daelemans, Jonas,Maes, Bert U. W.,Abbaspour Tehrani, Kourosch
, p. 18013 - 18017 (2019/06/24)
The iron(iii)-catalyzed efficient strategy for the synthesis of α-substituted homoallylamines was accomplished via a cationic 2-aza-Cope rearrangement of aldimines, generated in situ by condensation of commercially available aldehydes and easily synthesizable 1,1-diphenylhomoallylamines. This reaction features a broad substrate scope with high yields and is conducted in an eco-friendly solvent, i.e. dimethyl carbonate.
Arginase Inhibitors and Their Therapeutic Applications
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Paragraph 1091; 1092; 1093, (2017/11/29)
Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a
Iron-catalyzed oxidative C - H/C - H cross-coupling: An efficient route to α-quaternary α-amino acid derivatives
Li, Kaizhi,Tan, Guangying,Huang, Jingsheng,Song, Feijie,You, Jingsong
supporting information, p. 12942 - 12945 (2014/01/06)
Fully loaded: A coordinating activation strategy has been developed to furnish α-quaternary α-amino acids through the iron(III)-catalyzed oxidative functionalization of α-C(sp3) - H bonds of α-tertiary α-amino acid esters. The reaction exhibits a broad substrate scope for both α-amino acids and nucleophiles (Nu) as well as good functional-group tolerance (see scheme, DTBP=di-tert-butyl peroxide, DCE=1,2-dichloroethane). Copyright
The synthesis and characterization of a pentafluorosulfanylated peptide
Lim, Dong Sung,Lin, Jin-Hong,Welch, John T.
experimental part, p. 3946 - 3954 (2012/08/28)
The design and synthesis of pentafluorosulfanyl-containing heptad amino acid sequence was described. The three-dimensional conformation of the peptide was investigated by using CYANA (combined assignment and dynamics algorithm for NMR applications) and th
PENTAFLUOROSULFANYL CONTAINING AMINO ACIDS
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Page/Page column 12, (2008/12/08)
There are provided SF5-containing amino acids of general formulas (I), (II), (III) and processes for preparing same. Other embodiments are also disclosed.
HCV PROTEASE INHIBITORS
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Page/Page column 23, (2008/12/07)
This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.
C-C bond-forming reactions via Pd-mediated decarboxylative α-lmino anion generation
Yeagley, Andrew A.,Chruma, Jason J.
, p. 2879 - 2882 (2008/02/07)
α-lmino anions are generated under neutral reaction conditions via a Pd-mediated decarboxylation of allyl diphenylglycinate imines with concomitant formation of a π-allylpalladium species. The resulting delocalized anion can attack the π-allyl-Pd(ll) spec
A new synthetic approach to 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives via enyne metathesis and the Diels-Alder reaction
Kotha, Sambasivarao,Sreenivasachary, Nampally
, p. 503 - 504 (2007/10/03)
Various substituted 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives are synthesized via enyne metathesis and the Diels-Alder reaction.
Easy and efficient generation of reactive anions with free and supported ylides as neutral Bronsted bases
Palacios, Francisco,Aparicio, Domitila,De Los Santos, Jesús M.,Baceiredo, Antoine,Bertrand, Guy
, p. 663 - 669 (2007/10/03)
The tris(dimethylamino)-C-dimethylphosphorus ylide 5 and the tris(dimethylamino)phosphorus ylide C-bound to Merrifield's resin 6 are used as strong non-nucleophilic bases in N-alkylation reactions of β-amino phosphine oxides and α-amino acid derivatives,
