808752-08-1Relevant academic research and scientific papers
Serendipitous discovery of an unexpected rearrangement leads to two new classes of potential protease inhibitors
Zhong, Jiaying,Lai, Zhong,Groutas, Christopher S.,Wong, Tzutshin,Gan, Xiangdong,Alliston, Kevin R.,Eichhorn, David,Hoidal, John R.,Groutas, William C.
, p. 6249 - 6254 (2004)
The pathogenesis of a range of human diseases arises from the aberrant activity of proteolytic enzymes. Agents capable of selectively modulating the activity of these enzymes are of potential therapeutic value. Thus, there is a continuing need for the des
Formation of an unusual product in the reaction of a 1,2,5-thiadiazolidine 1,1-dioxide-derived thioether with sulfuryl chloride
Dou, Dengfeng,Talaty, Erach R.,Moore, Curtis E.,Bullinger, John C.,Eichhorn, David M.,Groutas, William C.
experimental part, p. 669 - 673 (2009/11/30)
(Chemical Equation Presented) The treatment of a 1,2,5-thiadiazolidine 1,1-dioxide-derived phenylthiomethyl ether with sulfuryl chloride yielded an unexpected dimeric product whose structure was determined using X-ray crystallography. A plausible mechanis
