81079-97-2Relevant academic research and scientific papers
Aryl substituted aminomethyl benzene derivatives having antiarrhythmic utility
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, (2008/06/13)
The present invention relates to new compounds of the formula STR1 wherein X is STR2 wherein R1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole, pyrazole oxazole or thiazole; W is hydrogen or hydroxy; (Y)A is positioned ortho to W and is an aminoloweralkyl having the formula --CH2 NR2 R3 where R2 and R3 are the same or different and may be lower alkyl or R2 and R3 may together with N form a pyrrolidine, piperidine or azepine ring, and A is 2; n and m are independently from 0 to 5; and R is straight or branched C1 -C10 alkyl, straight or branched C3 -C10 cycloalkyl, straight or branched C2 -C4 alkenyl or straight or branched C2 -C4 alkynyl, or a pharmaceutically acceptable salt thereof. These compounds are useful in the treatment of various cardiac arrhythmias.
Synthesis and Antiarrhythmic and Parasympatholytic Properties of Substituted Phenols. 2. Amides
Stout, David M.,Matier, W. L.,Barcelon-Yang, Cynthia,Reynolds, Robert D.,Brown, Barry S.
, p. 1347 - 1350 (2007/10/02)
Thirty amides patterned after the antiarrhythmic drug changrolin were synthesized and their antiarrhythmic and parasympatholytic activities were assessed. There was no correlation between antiarrhythmic and parasympatholytic activities. Several of the ami
