81099-86-7

Usage

Uses

An impurity of Amodiaquine (A634200) with antimalarial activity.

InChI:InChI=1/C15H11ClN2O/c16-10-1-6-13-14(7-8-17-15(13)9-10)18-11-2-4-12(19)5-3-11/h1-9,19H,(H,17,18)

Upstream product

• 6059-31-0 7-chloro-N-(4-methoxyphenyl)quinolin-4-amine 
• 86-98-6 4,7-dichloroquinoline 
• 123-30-8 4-amino-phenol 
• 51-78-5 p-aminophenol hydrochloride 
• 3648-96-2 4-amino-phenol; sulfate 
• 21617-15-2 7-chloro-1,2,3,4-tetrahydroquinolin-4-one 
• 100-02-7 4-nitro-phenol 
• 104-94-9 4-methoxy-aniline 
• 102021-96-5 4-p-anisidino-7-chloro-quinoline-3-carboxylic acid ethyl ester 
• 5570-84-3 7-chloro-4-(4-methoxy-anilino)-quinoline-3-carboxylic acid 
• 5507-39-1 2-(3-chloro-anilinomethylene)-N-(4-methoxy-phenyl)-malonamic acid ethyl ester 
• 5382-15-0 ethyl 3-((4-methoxyphenyl)amino)-3-oxopropanoate 
• 26413-49-0 1-acetyl-7-chloro-2,3-dihydro-1H-quinolin-4-one 

Downstream Products

• 132400-21-6 4-(7-chloro-quinolin-4-ylamino)-2-(morpholin-4-ylmethyl)phenol 
• 1312291-20-5 4-[(7-chloroquinolin-4-yl)amino]-2,6-bis(4-methylpiperazin-1-ylmethyl)phenol 
• 5201-88-7 4-<3,5-bis<(N-pyrrolidinyl)methyl>-4-hydroxyanilino>-7-chloroquinoline 
• 1312291-19-2 4-[(7-chloroquinolin-4-yl)amino]-2,6-bis(morpholin-4-ylmethyl)phenol 
• 132400-20-5 4-(7-chloro-[4]quinolylamino)-2-piperidinomethyl-phenol 
• 59219-61-3 4-(7'-chloroquinolin-4'-ylamino)-2,6-bis(diethylaminomethyl)phenol 
• 132400-18-1 4-(7-chloro-quinolin-4-ylamino)-2-dibutylaminomethyl-phenol 

Relevant academic research and scientific papers

Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms

The ligand-activated transcription factor nuclear receptor related-1 (Nurr1) exhibits great potential for neurodegenerative disease treatment, but potent Nurr1 modulators to further probe and validate the nuclear receptor as a therapeutic target are lacki

7-CHLORO-QUINOLIN-4-AMINE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS

The present invention relates to compounds having the following Formula (I) for use in the prevention and/or the treatment of diseases involving formation of amyloid plaques and/or where a dysfunction of the APP metabolism occurs.

Synthesis and in vitro antiplasmodial activity of quinoline-ferrocene esters

New 4-aminoquinoline-derived esters containing the redox-active ferrocene group brought in by either ferrocenyformic or 4-ferrocenylbutanoic acids were synthesized and tested in vitro for their antiplasmodial activity. The results revealed that only ester

Microwave-accelerated solvent- and catalyst-free synthesis of 4-aminoaryl/alkyl-7-chloroquinolines and 2-aminoaryl/alkylbenzothiazoles

An efficient synthesis of 4-aminoaryl/alkyl-7-chloroquinolines and 2-aminoaryl/alkylbenzothiazoles has been developed by microwave-accelerated regioselective aromatic nucleophilic substitution of 4,7-dichloroquinoline and 2-chlorobenzothiazole with aromatic and aliphatic amines under solvent-free conditions in the absence of any added protic or Lewis acid catalyst. Chemoselective reaction with the amino group in preference to the phenolic hydroxy group was observed. Thus, the treatment of 4,7-dichloroquinoline (1 equiv.) with a mixture of aniline (2 equiv.) and phenol (2 equiv.) afforded exclusive formation of 4-aminophenyl-7-chloroquinoline. When 4,7-dichloroquinoline (1 equiv.) was separately treated with 2-aminophenol (2 equiv.) and 4-aminophenol (2 equiv.), 4-(2'-hydroxyphenyl)-7-chloroquinoline and 4-(4'-hydroxyphenyl)-7-chloroquinoline, respectively, were formed. CSIRO 2007.

Process for the preparation of 4-amino-chloroquinolines

4-Amino-chloroquinolines of the formula: STR1 in which R1 represents a hydrogen atom or an alkyl radical (1 to 5 carbon atoms), and R2 represents an alkyl radical (1 to 5 carbon atoms) optionally substituted by a dialkylamino group, or a phenyl radical optionally substituted by one or more carboxy and hydroxy radicals and alkyl radicals (1 to 4 carbon atoms) optionally substituted by a dialkylamino group, are prepared by the condensation of an amine of the formula: STR2 with a chloro-1,2,3,4-tetrahydroquinolin-4-one of the formula: STR3 with aromatization of the tetrahydroquinoline, the reaction being carried out in the presence of a ruthenium based catalyst on a support. The 4-amino-chloroquinoline products are useful as pharmaceuticals.