81259-56-5

Basic information

• Product Name: 4-ETHOXY-3-METHOXYBENZONITRILE
• Synonyms: 4-ETHOXY-3-METHOXYBENZONITRILE;AKOS B004323;AKOS BBS-00001424
• CAS NO: 81259-56-5
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Mol File: 81259-56-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-ETHOXY-3-METHOXYBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHOXY-3-METHOXYBENZONITRILE(81259-56-5)
• EPA Substance Registry System: 4-ETHOXY-3-METHOXYBENZONITRILE(81259-56-5)

Safety Data

• Hazardous Substances Data: 81259-56-5(Hazardous Substances Data)

Upstream product

• 3535-24-8 4-ethoxy-3-methoxybenzoic acid methyl ester 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 3535-30-6 4-ethoxy-3-methoxybenzoic acid 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 74-96-4 ethyl bromide 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 
• 247569-93-3 4-ethoxy-3-methoxy-benzoic acid amide 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 
• 81259-53-2 4-ethoxy-3-methoxybenzaldehyde oxime 
• 81259-53-2 4-ethoxy-3-methoxy-benzaldehyde seqtrans-oxime 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 98-09-9 benzenesulfonyl chloride 
• 75-03-6 ethyl iodide 
• 81259-53-2 4-ethoxy-3-methoxy-benzaldehyde seqcis-oxime 

Downstream Products

• 93489-14-6 4-ethoxy-3-methoxy-benzylamine 
• 108439-67-4 3-ethoxy-4-methoxybenzylamine 
• 1048698-60-7 7-ethoxy-4-(3-fluoro-4-bromoanilino)-6-methoxy-1,2,3-benzotriazine 
• 1048698-67-4 7-ethoxy-6-methoxy-4-(3-trifluoromethylanilino)-1,2,3-benzotriazine 
• 1122661-14-6 2-amino-4-ethoxy-5-methoxybenzonitrile 
• 1048698-68-5 7-ethoxy-6-methoxy-4-(4-trifluoromethylanilino)-1,2,3-benzotriazine 
• 1048698-69-6 7-ethoxy-6-methoxy-4-(3-trifluoromethoxyanilino)-1,2,3-benzotriazine 
• 1048698-70-9 7-ethoxy-6-methoxy-4-(4-trifluoromethoxyanilino)-1,2,3-benzotriazine 
• 1048698-71-0 4-(3-chloroanilino)-7-ethoxy-6-methoxy-1,2,3-benzotriazine 
• 1048698-73-2 7-ethoxy-4-(4-fluoro-3-trifluoromethylanilino)-6-methoxy-1,2,3-benzotriazine 
• 1048698-74-3 7-ethoxy-4-(2-fluoroanilino)-6-methoxy-1,2,3-benzotriazine 
• 1048698-75-4 4-(3-bromoanilino)-7-ethoxy-6-methoxy-1,2,3-benzotriazine 
• 247568-34-9 2-fluoro-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Structure-activity relationship studies of SETD8 inhibitors

SETD8 (also known as SET8, PR-SET7, or KMT5A (lysine methyltransferase 5A)) is the only known lysine methyltransferase that catalyzes the monomethylation of histone H4 lysine 20 (H4K20). In addition to H4K20, SETD8 monomethylates non-histone substrates such as the tumor suppressor p53 and the proliferating cell nuclear antigen (PCNA). Because of its role in regulating diverse biological processes, SETD8 has been pursued as a potential therapeutic target. We recently reported the first substrate-competitive SETD8 inhibitor, UNC0379 (1), which is selective for SETD8 over 15 other methyltransferases. We characterized this inhibitor in a battery of biochemical and biophysical assays. Here we describe our comprehensive structure-activity relationship (SAR) studies of this chemical series. In addition to 2- and 4-substituents, we extensively explored 6- and 7-substituents of the quinazoline scaffold. These SAR studies led to the discovery of several new compounds, which displayed similar potencies as compound 1 and interesting SAR trends. This journal is

Design, synthesis, and antitumor activities of some novel substituted 1,2,3-benzotriazines

A series of novel substituted 1,2,3-benzotriazines based on the structures of vatalanib succinate (PTK787) and vandetanib (ZD6474) were designed and synthesized. The antiproliferative effects of these compounds were tested on microvascular endothelial cel