81265-15-8

Upstream product

• 67-56-1 methanol 
• 5468-05-3 2-(benzyl)-4-methyl-1,3-dioxolane 
• 59950-99-1 α-chlorophenylacetaldehyde dimethyl acetal 
• 74-87-3 methylene chloride 
• 124-38-9 carbon dioxide 
• 98-07-7 Benzotrichlorid 
• 22979-35-7 Methyl phenyldiazoacetate 

Downstream Products

• 61031-72-9 dichlorophenyl-acetic acid 
• 4773-36-8 2,2-dichloro-2-phenylacetyl chloride 
• 197857-86-6 N-allyl-N-benzyl-2,2-dichloro-2-phenylacetamide 

Relevant academic research and scientific papers

Dihaloiodoarenes: α,α-dihalogenation of phenylacetate derivatives

A hypervalent iodine reagent-based α-carbonyl dihalogenation reaction is reported. Treating diazoacetate derivatives with either iodobenzene dichloride or iodotoluene difluoride results in gem-dichlorination or gem-difluorination products, respectively. The reaction is catalyzed by either Lewis acid or Lewis base activation of the aryl-λ3-iodane (ArIX2) species and proceeds rapidly and chemoselectively to the desired gem-difunctionalized products in good to excellent yield.

Preparation of 2,2-Dihalocarboxylic Acid Methyl Esters by Oxidation-Chlorination of 2-(1-Haloalkyl)-4-methyl-1,3-dioxolanes with Trichloroisocyanuric Acid

Methyl 2,2-dichloro or 2-bromo-2-chloro carboxylates were obtained in excellent yields by oxidation-chlorination of 2-(1-haloalkyl)-4-methyl-1,3-dioxolanes with trichloroisocyanuric acid.

Trichloroisocyanuric Acid Oxidation of 2-Chloro Aldehyde Acetals to 2-Chloro Acids Esters

2-Chloro acid methyl esters were prepared in good yields treating 2-chloro aldehyde dimethyl acetals with trichloroisocyanuric acid in DMF.Aldehyde dimethyl acetals with the 2-halogen on a tertiary carbon atom were poorly reactive and could be oxidized efficiently only after their transformation into 1,3-dioxolanes.

Methyl α,α-dichloro-esters by oxidation-chlorination of cyclic acetals with trichloroisocyanuric acid

Methyl α-chloro- or α,α-dichloro-esters are obtained in excellent yields by oxidation chlorination of 2-alkyl-4,5-dimethyl-1,3-dioxolanes with trichloroisocyanuric acid.

Electrochemical Reduction of Trichloromethylbenzene II Reduction in the Presence of Electrophiles

Electrochemical reduction of trichloromethylbenzene at a mercury electrode in DMF/TBABF4 in the presence of acetic anhydride gives 1,2-diacetoxy-1-phenylpropene as major product; minor products are dichloromethylbenzene and dimerized products.During the reduction 1,1-dichloro-1-phenyl-2-propane and 2-acetoxy-1-chloro-1-phenylpropene can be detected.With sodium perchlorate as supporting electrolyte 1-chloro-1-phenyl-2-propanone and 1-acetoxy-1-phenyl-2-propanone are formed; these products are also formed during the reduction of benzal chloride in the presence of acetic anhydride.Reductive carboxylation of trichloromethylbenzene gives 2,2-dichloro-2-phenylacetic acid.