81340-59-2Relevant academic research and scientific papers
Reaction between harmaline and vanillin to produce dimeric scaffolds that exhibit anti-proliferative activity
Birar, Vishal C.,Zaid, Gene,Blagg, Brian S.J.
, (2021)
Herbal medicine is used as a complement to modern medicine for the treatment of human diseases such as cancer, inflammation, and diabetes. Nutraceutical components in foods such as vanillin produce antioxidant and anticancer activities and many of these p
FUSED POLYCYCLIC DIMERS
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Page/Page column 18; 19; 20, (2021/02/12)
Novel fused tricyclic or bicyclic dimers, such as β-carboline and quinoline moieties with a central linker, exhibit anti-cancer activities against a variety of human cancer cell lines. The dimer compounds can be used in anti-cancer therapeutic composition
Iron-catalysed alkylation of 2-methyl and 4-methyl azaarenes with alcoholsviaC-H bond activation
Banerjee, Debasis,Bera, Sourajit,Kabadwal, Lalit Mohan
, p. 4777 - 4780 (2020/05/13)
The first Fe-catalysed alkylation of 2-methyl and 4-methyl-azaarenes with a series of alkyl and hetero-aryl alcohols is reported (>39 examples and up to 95% yield). Multi-functionalisation of pyrazines and synthesis of anti-malarial drug (±) Angustureine significantly broaden the scope of this methodology. Preliminary mechanistic investigation, deuterium labeling and kinetic experiments including trapping of the enamine intermediate1a'are of special importance.
Catalyst-free synthesis of (E)-2-alkenylquinoline derivatives via C(sp3)-H functionalization of 2-methylquinolines
Xu, Lubin,Shao, Zhuzhou,Wang, Liang,Zhao, Huaili,Xiao, Jian
supporting information, p. 6856 - 6860 (2015/01/09)
This Letter described a facile approach to synthesize (E)-2-alkenylquinoline derivatives via C(sp3)-H functionalization of 2-methylquinolines under catalyst-free conditions. A variety of electronically and sterically diverse 2-methyl quinoline and aromatic aldehydes were well tolerated.
Br?nsted acid catalyzed synthesis of 1,3-di(2-quinolyl)propane derivatives via tandem C(sp3)-H functionalization
Jin, Jia-Jia,Wang, Dong-Chao,Niu, Hong-Ying,Wu, Shan,Qu, Gui-Rong,Zhang, Zhong-Bo,Guo, Hai-Ming
, p. 6579 - 6584 (2013/07/25)
A novel protocol for Br?nsted acid catalyzed reaction of 2-methyl azaarenes and aromatic aldehyde to give 1,3-di(2-quinolyl)propane derivatives through tandem C(sp3)-H bond functionalization has been developed. This approach provides a new access to a variety of 1,3-di(2-quinolyl)propane derivatives, which are potentially of great importance in pharmaceuticals and ligand fields.
