81340-59-2Relevant articles and documents
Reaction between harmaline and vanillin to produce dimeric scaffolds that exhibit anti-proliferative activity
Birar, Vishal C.,Zaid, Gene,Blagg, Brian S.J.
, (2021)
Herbal medicine is used as a complement to modern medicine for the treatment of human diseases such as cancer, inflammation, and diabetes. Nutraceutical components in foods such as vanillin produce antioxidant and anticancer activities and many of these p
Iron-catalysed alkylation of 2-methyl and 4-methyl azaarenes with alcoholsviaC-H bond activation
Banerjee, Debasis,Bera, Sourajit,Kabadwal, Lalit Mohan
, p. 4777 - 4780 (2020/05/13)
The first Fe-catalysed alkylation of 2-methyl and 4-methyl-azaarenes with a series of alkyl and hetero-aryl alcohols is reported (>39 examples and up to 95% yield). Multi-functionalisation of pyrazines and synthesis of anti-malarial drug (±) Angustureine significantly broaden the scope of this methodology. Preliminary mechanistic investigation, deuterium labeling and kinetic experiments including trapping of the enamine intermediate1a'are of special importance.
Br?nsted acid catalyzed synthesis of 1,3-di(2-quinolyl)propane derivatives via tandem C(sp3)-H functionalization
Jin, Jia-Jia,Wang, Dong-Chao,Niu, Hong-Ying,Wu, Shan,Qu, Gui-Rong,Zhang, Zhong-Bo,Guo, Hai-Ming
, p. 6579 - 6584 (2013/07/25)
A novel protocol for Br?nsted acid catalyzed reaction of 2-methyl azaarenes and aromatic aldehyde to give 1,3-di(2-quinolyl)propane derivatives through tandem C(sp3)-H bond functionalization has been developed. This approach provides a new access to a variety of 1,3-di(2-quinolyl)propane derivatives, which are potentially of great importance in pharmaceuticals and ligand fields.