81542-09-8

Basic information

• Product Name: Benzoicacid, 4-methoxy-, hexyl ester
• Synonyms: Hexyl 4-methoxybenzoate; NSC 309837
• CAS NO: 81542-09-8
• Molecular Formula: C14H20 O3
• Molecular Weight: 236.311
• Mol File: 81542-09-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzoicacid, 4-methoxy-, hexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoicacid, 4-methoxy-, hexyl ester(81542-09-8)
• EPA Substance Registry System: Benzoicacid, 4-methoxy-, hexyl ester(81542-09-8)

Safety Data

• Hazardous Substances Data: 81542-09-8(Hazardous Substances Data)

Upstream product

• 402-52-8 methyl 4-(trifluoromethyl)phenyl ether 
• 111-27-3 hexan-1-ol 
• 121-98-2 methyl 4-methoxybenzoate 
• 105-13-5 4-Methoxybenzyl alcohol 
• 592-41-6 1-hexene 
• 100-09-4 4-methoxybenzoic acid 
• 3424-93-9 4-methoxyphenylacetamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 3400-22-4 4-methoxy-N-methylbenzamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 75748-09-3 (4-methoxybenzoyl)trimethylsilane 

Relevant articles and documents

Acceptorless Dehydrogenative Cross-Coupling of Primary Alcohols Catalyzed by an N-Heterocyclic Carbene-Nitrogen-Phosphine Chelated Ruthenium(II) Complex

The acceptorless dehydrogenative cross-coupling of primary alcohols to form cross-esters with the liberation of H2 gas was enabled using a [RuCl(η6-C6H6)(κ2-CNP)][PF6]Cl complex as the catalyst. This sustainable protocol is applicable to a broad range of primary alcohols, particularly for the sterically demanding ones, featuring good functional group tolerance and high selectivity. The good catalytic performance can be attributed to the nitrogen-phosphine-functionalized N-heterocyclic carbene (CNP) ligand, which adopts a facial coordination mode as well as the facile dissociation of coordinated benzene.

Epoxide as precatalyst for metal-free catalytic transesterification

Transesterification of methyl esters was accelerated by an in situ-generated metal-free catalyst comprising a quaternary alkylammonium salt and an epoxide. The combination of a quaternary alkylammonium acetate and glycidol is optimal, and various esters were synthesized from methyl esters with alcohols in good to excellent yield. Analysis of the catalyst solution revealed that basic species are generated by the ring-opening reaction of epoxide.

Cesium Carbonate Catalyzed Esterification of N-Benzyl- N-Boc-amides under Ambient Conditions

We report a general activated amide to ester transformation catalyzed by Cs2CO3. Using this approach, esterification proceeds under relatively mild conditions and without the need for a transition metal catalyst. This method exhibits broad substrate scope and represents a practical alternative to existing esterification strategies. The synthetic utility of this protocol is demonstrated via the facile synthesis of crown ether derivatives and the late-stage modification of a representative natural product and several sugars in reasonable yields.