75748-09-3

Basic information

• Product Name: Silane, (4-methoxybenzoyl)trimethyl-
• CAS NO: 75748-09-3
• Molecular Formula: C11H16O2Si
• Molecular Weight: 208.332
• Mol File: 75748-09-3.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Silane, (4-methoxybenzoyl)trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, (4-methoxybenzoyl)trimethyl-(75748-09-3)
• EPA Substance Registry System: Silane, (4-methoxybenzoyl)trimethyl-(75748-09-3)

Safety Data

• Hazardous Substances Data: 75748-09-3(Hazardous Substances Data)

Upstream product

• 18000-27-6 trimethylsilyllithium 
• 100-07-2 4-methoxy-benzoyl chloride 
• 75-77-4 chloro-trimethyl-silane 
• 24588-72-5 2-(4-methoxyphenyl)-1,3-dithiane 
• 21960-26-9 (4-methoxybenzylidene)triphenylphosphorane 
• 17955-46-3 trimethylsilyltributyltin 
• 99328-19-5 [(4-Methoxy-phenyl)-trimethylsilanyl-methylene]-triphenyl-λ⁵-phosphane 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 76943-81-2 [Dibromo-(4-methoxy-phenyl)-methyl]-trimethyl-silane 
• 132274-45-4 2-(4-Methoxyphenyl)-2-(trimethylsilyl)-1,3-dithiane 
• 123-11-5 4-methoxy-benzaldehyde 
• 23837-15-2 1-(bis(ethylthio)methyl)-4-methoxybenzene 
• 6712-20-5 2-(4-methoxyphenyl)-[1,3]dithiolane 

Downstream Products

• 144968-95-6 2,2,3,3,3-Pentafluoro-1-(4-methoxy-phenyl)-1-trimethylsilanyl-propan-1-ol 
• 144968-96-7 2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoro-1-(4-methoxy-phenyl)-1-trimethylsilanyl-heptan-1-ol 
• 151961-18-1 (E)-Perfluorohex-1-enyl 4-methoxyphenyl ketone 
• 121-98-2 methyl 4-methoxybenzoate 
• 94-30-4 ethyl 4-methoxybenzoate 
• 6938-38-1 4-methoxy-benzoic acid isopropyl ester 
• 6316-54-7 4-methoxy-benzoic acid benzyl ester 
• 833-79-4 t-butyl 4-methoxybenzoate 
• 100-09-4 4-methoxybenzoic acid 
• 81542-09-8 hexyl p-methoxybenzoate 
• 7469-80-9 cyclohexyl 4-methoxyphenyl ketone 
• 17988-20-4 (4-methoxy-benzyl)-trimethyl-silane 
• 1185262-53-6 2-(furan-2-yl)-1-(4-methoxyphenyl)-2-(trimethylsilyloxy)propan-1-one 
• 1185262-55-8 C₂₀H₂₆O₄Si 

Relevant articles and documents

Chemoselective Amide-Forming Ligation Between Acylsilanes and Hydroxylamines Under Aqueous Conditions

We report the facile amide-forming ligation of acylsilanes with hydroxylamines (ASHA ligation) under aqueous conditions. The ligation is fast, chemoselective, mild, high-yielding and displays excellent functional-group tolerance. Late-stage modifications of an array of marketed drugs, peptides, natural products, and biologically active compounds showcase the robustness and functional-group tolerance of the reaction. The key to the success of the reaction could be the possible formation of the strong Si?O bond via a Brook-type rearrangement. Given its simplicity and efficiency, this ligation has the potential to unfold new applications in the areas of medicinal chemistry and chemical biology.

Visible-Light Mediated Tryptophan Modification in Oligopeptides Employing Acylsilanes

A method for the selective tryptophan modification and labelling of tryptophan-containing peptides is described. Photoirradiation of acylsilanes generates reactive siloxycarbenes which undergo H?N-insertion into the indole moiety of tryptophan to give stable silyl protected hemiaminals. This method is successfully applied to chemically modify various tryptophan containing oligopeptides. The method enables the selective introduction of alkynes to peptides that are eligible for further alkyne-azide click chemistry. In addition, the dansyl fluorophore can be conjugated to a peptide using this approach.

Oxidative [1,2]-Brook Rearrangements Exploiting Single-Electron Transfer: Photoredox-Catalyzed Alkylations and Arylations

Oxidative [1,2]-Brook rearrangements via hypervalent silicon intermediates induced by photoredox-catalyzed single-electron transfer have been achieved, permitting the formation of reactive radical species that can engage in alkylations and arylations.