81678-16-2

Usage

Uses

Used in Molecular Dynamics Studies:
Leucine Enkephalin Acetate Salt is utilized as a model neurotransmitter in molecular dynamics studies. It aids researchers in understanding the insertion and interaction of neurotransmitters with lipid bilayer membranes, which is vital for comprehending the mechanisms of neuronal signaling and membrane stability.
Used in Pharmaceutical Research:
Leucine Enkephalin Acetate Salt serves as a key component in pharmaceutical research, particularly in the development of pain management therapies and treatments targeting the opioid system. Its interaction with delta-opioid receptors makes it a valuable candidate for the design of drugs with potential applications in pain relief and addiction treatment.
Used in Neurobiology:
In the field of neurobiology, Leucine Enkephalin Acetate Salt is employed to study the mechanisms of pain perception, stress response, and the overall functioning of the nervous system. Understanding the role of this neurotransmitter can lead to advancements in the treatment of neurological disorders and the development of more effective analgesics.
Used in Drug Design and Development:
Leucine Enkephalin Acetate Salt is used as a template in drug design and development, particularly for the creation of peptide-based drugs and therapies. Its structure and function provide insights into the design of molecules that can modulate the opioid system, potentially leading to the development of safer and more effective pain management treatments.

Upstream product

• 138372-38-0 Fmoc-Tyr(OBu^t)-Gly-Gly-Phe-Leu-OBu^t 
• 89137-25-7 (S)-2-((S)-2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester 
• 77066-56-9 benzyl-L-penylalanyl-L-leucinate trifluoroacetic acid 
• 61543-55-3 Z-Tyr-Gly-Gly hydrazide 
• 427881-22-9 (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-tert-butoxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester 
• 64-19-7 acetic acid 
• 69729-16-4 N-benzyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine benzyl ester 
• 149204-99-9 Fmoc-Gly-L-Phe-L-Leu-OtBu 
• 84891-01-0 Fmoc-Phe-Leu-OtBu 
• 77426-98-3 Gly-Gly-Phe-Leu-OBu^t 
• 82362-19-4 Gly-Phe-Leu(t-Bu) 
• 28635-78-1 L-phenylalanyl-L-leucine tert-butyl ester 
• 2748-02-9 L-leucine tert-butyl ester hydrochloride 
• 35661-40-6 N-Fmoc L-Phe 

Downstream Products

• 63-91-2 L-phenylalanine 
• 673-08-5 YG 
• 3303-55-7 L-Phe-Leu 
• 21778-69-8 tyrosylglycylglycine 
• 60-18-4 L-tyrosine 
• 60254-83-3 [des-tyr¹]-leucine enkephalin 

Relevant academic research and scientific papers

A RAPID NON-ACIDOLYTIC METHOD FOR DEPROTECTION AND REMOVAL OF PEPTIDES FROM SOLID PHASE RESINS - APPLICATIONS OF AMMONIUM FORMATE CATALYTIC TRANSFER HYDROGENATION

Ammonium formate aided catalytic transfer hydrogenation has been employed in the cleavage, and concommitant deprotection, of the pentapeptide leucine enkephalin from the Merrifield peptide resin under ambient conditions of temperature and pressure in a neutral medium.

A new method for rapid solution synthesis of shorter peptides by use of PyBOP

By using PyBOP promoted coupling of Fmoc protected amino acids, and adopting the deprotection/washing procedure of the Fmoc Amino Acid Chloride Solution Technique (FAACST), a sample of [leucine5] enkephalin has been synthesized in a rapid, cont