818-92-8Relevant articles and documents
Displacement Dynamics of Fluorine Atoms Reacting with Allyl Bromide Molecules
Zhu, Z. Z.,Smith, D. J.,Grice, R.
, p. 4008 - 4011 (1994)
Reactive scattering of F atoms with C3H5Br molecules leading to Br atom displacement has been studied at an initial translational energy E ca. 40 kJ mol-1 using a supersonic beam of F atoms seed in He buffer gas.The center-of-mass angular distribution of C3H5F scattering shows a broad peak in the forward direction with roughly constant relative intensity ca. 0.4 in the backward hemisphere.The product translational energy distribution peaks at a low fraction f'pk ca. 0.1 of the total available energy with a tail extending up to higher energy.The reaction dinamics involve a stripping mechanism whereby the F atom adds to the C=C double bond, forming either the secondary fluorobromopropyl radical which dissociates directly to form allyl fluoride reaction product by bonding to the terminal CH2 group or the primary fluorobromopropyl radical which may dissociate by ring closure to form fluorocyclopropane reaction product by bonding to the intermediate CH group.The suggested occurence of two reaction pathways is inferred from the absence of H atom or CH2Br radical displacement pathways since the mass spectrometer detector does not distinguish between the proposed reaction products.
Efficient protocol for the SO2F2-mediated deoxyfluorination of aliphatic alcohols
Epifanov, Maxim,Lai, Joey,Lee, Cayo,Sammis, Glenn M.,Wang, Cindy Xinyun
supporting information, (2021/09/28)
Alkyl fluorides are prevalent in both the pharmaceutical and agrochemical industries. As such, there has been significant interest over the past 40 years in the development of new synthetic methods to access these important fluorinated motifs. Herein we report the sulfuryl fluoride-mediated deoxyfluorination of alcohols using room temperature reaction conditions in only an hour. A wide range of primary aliphatic alcohols were efficiently converted to the corresponding fluoride in 46-70% isolated yields. Secondary alcohols were also effectively deoxyfluorinated in 50–92% yields. Chiral secondary alcohols were cleanly converted to the corresponding alkyl fluoride with only a minor deterioration of the enantioenrichment. A steroid derivative also underwent deoxyfluorination in 50% yield and 5.9:1 dr, with the major product resulting from net inversion of the stereocenter.
PRODUCTION OF COMPOUNDS COMPRISING CF30 GROUPS
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Page/Page column 5, (2011/04/24)
The present invention relates to a process for the preparation of compounds containing CF3O groups using compounds containing at least one group Y, in which Y=—Hal, —OSO2(CF2)zF, —OSO2CzH2z+1 (z=1-10), —OSO2F, —OSO2Cl, —OC(O)CF3— or —OSO2Ar, to a process for the preparation of compounds containing CF3O groups using KOCF3 and/or RbOCF3, and to novel compounds containing CF3O groups, and to the use thereof.
