819796-92-4

Upstream product

• 100-59-4 phenylmagnesium chloride 
• 819796-91-3 2(R)-N-(tert-butoxycarbonyl)-N'-methoxy-N'-methylphenylglycinamide 
• 147353-99-9 tert-butyl 2-(methoxy(methyl)amino)-2-oxo-1-phenylethylcarbamate 
• 451-40-1 phenyl benzyl ketone 
• 4248-19-5 tert-butyl carbazate 
• 3469-17-8 2-diazo-1,2-diphenylethan-1-one 
• 33125-05-2 Boc-D-Phg-OH 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 142560-68-7 (1R,2S)-(+)-tert-butyl 2-hydroxy-1,2-diphenylethylcarbamate 

Relevant academic research and scientific papers

Enantioselective N-H insertion reaction of α-aryl α-diazoketones: An efficient route to chiral α-aminoketones

A highly enantioselective N-H insertion reaction of α-diazoketones was developed by using cooperative catalysis by dirhodium(II) carboxylates and chiral spiro phosphoric acids. The insertion reaction provides a new access route to diverse chiral α-aminoketones, which are versatile building blocks in organic synthesis, with fast reaction rates, good yields and high enantioselectivity under mild and neutral conditions. Spiro inspiration: A highly enantioselective N-H insertion reaction of α-diazoketones was developed by using cooperative catalysis by dirhodium(II) carboxylates and chiral spiro phosphoric acids. The insertion reaction provides a new access route to diverse chiral α-aminoketones, which are versatile building blocks in the organic synthesis, with fast reaction rates, good yields and high enantioselectivity under mild and neutral conditions.

Asymmetrie imino aza-enamine reaction catalyzed by axially chiral dicarboxylic acid: Use of arylaldehyde N,N-dialkylnydrazones as acyl anion equivalent

Synthetic utility of arylaldehyde N,N-dialkylhydrazones as a practical acyl anion equivalent could be exploited for the first time in the asymmetric imino aza-enamine reaction catalyzed by axially chiral carboxylic acid. Copyright

Stille coupling of stereochemically defined α- sulfonamidoorganostannanes

Addition of tributylstannylmetallics to (R)-tert-butanesulfonimine derivatives of arylaldehydes provides α-sulfinamidostannanes with high (>98% de) diastereoselectivities. Oxidation of these compounds with m-CPBA gives α-sulfonamidostannanes which undergo Pd/Cu-catalyzed Stille-type couplings with benzoyl chloride. Best yields are achieved using the electron-rich tris(2,4,6-trimethoxyphenyl)phosphine as the ligand. Inversion of configuration at the benzylic carbon is observed. Copyright