82326-77-0Relevant academic research and scientific papers
Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity
ElZahabi, Heba S.A.,Nafie, Mohamed S.,Osman, Dina,Elghazawy, Nehal H.,Soliman, Dalia H.,EL-Helby, Abdelghany Ali H.,Arafa, Reem K.
, (2021/06/15)
This work presents the design and synthesis of a series of new quinazolin-4-one derivatives, based on the established effectiveness of quinazoline-based small molecules as anticancer agents. Synthesized compounds were more potent against MCF-7 than A-549
Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases
Baska, Ferenc,Sipos, Anna,?rfi, Zoltán,Nemes, Zoltán,Dobos, Judit,Szántai-Kis, Csaba,Szabó, Eszter,Szénási, Gábor,Dézsi, László,Hamar, Péter,Cserepes, Mihály T.,Tóvári, József,Garamv?lgyi, Rita,Krekó, Marcell,?rfi, László
, (2019/10/16)
Aberrant activation of FMS-like tyrosine receptor kinase 3 (FLT3) is implicated in the pathogenesis of acute myeloid leukemia (AML) in 20–30% of patients. In this study we identified a highly selective (phenylethenyl)quinazoline compound family as novel potent inhibitors of the FLT3-ITD and FLT3-D835Y kinases. Their prominent effects were confirmed by biochemical and cellular proliferation assays followed by mice xenograft studies. Our modelling experiments and the chemical structures of the compounds predict the possibility of covalent inhibition. The most effective compounds triggered apoptosis in FLT3-ITD AML cells but had either weak or no effect in FLT3-independent leukemic and non-leukemic cell lines. Our results strongly suggest that our compounds may become therapeutics in relapsing and refractory AML disease harboring various ITD and tyrosine kinase domain mutations, by their ability to overcome drug resistance.
STYRYL QUINAZOLINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE AGENTS
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Page/Page column 8; 9, (2015/02/25)
The present invention relates to styryl quinazoline derivatives of the general formula (I) and pharmaceutically acceptable solvates, hydrates, salts, regioisomeric and polymorphic forms thereof as well as pharmaceutical compositions containing at least on
Synthesis of quinazolin-4-(3H)-ones from o-amidobenzonitriles using urea-hydrogen peroxide
Bandgar
, p. 2065 - 2068 (2007/10/03)
Synthesis of quinazolin-4-(3H)-ones from o-amido-benzonitriles has been carried out by using urea-hydrogen peroxide as a mild, stable and non- hazardous reagent.
6,8-Dibromo-2-methyl-1,3-4(3H)-quinazolinones
Ossmann, A. E.,El-Zahabi, M. M.,El-Hakim, A. E.,Osman, A. N.
, p. 113 - 114 (2007/10/02)
Hydrazinolysis of 6,8-dibromo-2-methyl-3,1-benzoxazin-4-(H)-one (1) afforded the 3-amino-6,8-dibromo-2-methyl-1,3,4(3H)-quinazoline (2a).Acylation of the latter with acetic anhydride and benzoyl chloride yielded the corresponding acetyl and benzoyl deriva
