82408-02-4Relevant articles and documents
A novel magnetic nanocatalyst Fe3O4@TiO2-H5IO6 for the green synthesis of 4-substituted-1,5-benzodiazepine derivatives
Ahmadzadeh, Fatemeh,Etemad, Jamileh,Farahi, Mahnaz,Karami, Bahador
, p. 456 - 465 (2021/08/21)
In this study, periodic acid-functionalized magnetic support (Fe3O4@TiO2-H5IO6) as a new, benign and recyclable nanocatalyst was prepared by anchoring / periodic acid onto TiO2-coated nano-Fe3O4. This catalyst was applied to achieve a high-efficiency, low-cost and eco-friendly approach for synthesizing 4-substituted-1,5-benzodiazepines with the multicomponent reactions of aromatic aldehydes, o-phenylenediamine, and dimedone. The / periodic acid group on Fe3O4@TiO2 possesses both Lewis and Br?nsted acidity, which is responsible for the high catalyst activity. The obtained results show that the catalyst performance has been acceptable in the presented research. / The catalyst could be recovered and reused up to six times without any notable decrease in its activity.
A nickel nanoparticle engineered CoFe2O4@GO-Kryptofix 22 composite: A green and retrievable catalytic system for the synthesis of 1,4-benzodiazepines in water
Mozafari, Roya,Ghadermazi, Mohammad
, p. 15052 - 15064 (2020/05/05)
A composite of Ni nanoparticles incorporated in Kryptofix 22 conjugated magnetic nano-graphene oxide, CoFe2O4@GO-K 22·Ni, was synthesized via the grafting of Kryptofix 22 moieties on the magnetic nano-graphene oxide surface, followed by reaction of the nanocomposite with nickel nitrate. The Kryptofix 22 host material unit cavities can stabilize the Ni nanoparticles effectively and prevent their aggregation and separation from the surface. Characterization of the catalysts by FT-IR, FE-SEM, TGA, ICP, EDX, XRD, VSM and BET aided understanding the catalyst structure and morphology. This catalyst was efficiently applied for the synthesis of 1,4-benzodiazepine derivatives. The main advantages of the method are mild reaction conditions, inexpensive catalyst, it is environmentally benign, has high to excellent yields and shorter reaction times. This organometallic catalyst can be easily separated from a reaction mixture and was successfully examined for six runs with a slight loss of catalytic activity.
Synthesis and characterization of CoFe2O4@SiO2@NH-NH2-PCuW as an acidic nano catalyst for the synthesis of 1,4-benzodiazepines and a powerful dye remover
Savari, Ali,Heidarizadeh, Fariba,Pourreza, Nahid
, p. 233 - 247 (2019/05/08)
A novel magnetic heterogeneous nanocatalyst CoFe2O4@SiO2@NH-NH2-PCuW was synthesized and characterized. This powerful catalyst possesses Br?nsted and Lewis acid properties. The presence of Cu enhances the acidity of this catalyst because of the increase in the electron deficiency of polyoxometalate. It was successfully applied for the easy and efficient one-pot synthesis of 1,4-benzodiazepine derivatives directly from dimedone, o-phenylenediamine, and an aromatic aldehyde under a solvent-free condition at 80 °C. High yields in short reaction times, easy work-up, and environmental friendliness are some of the advantages of this protocol. Also, this nanocatalyst could conveniently be recovered by a magnetic field and reused several times without a significant loss of catalytic efficiency. The synthesized nanocatalyst CoFe2O4@SiO2@NH-NH2-PCuW also proved to be an excellent adsorbent for dye removal. These properties are related to the high surface area because of the nanostructure and high acidity due to the presence of Cu in polyoxometalate. Moreover, magnetic properties help better recovering of this adsorbent for dye removed from wastewater.
Organocatalytic Green Approach Towards the Fabrication of Fused Benzo N,N-containing Heterocycles Facilitated by Ultrasonic Irradiation
Nongrum, Ridaphun,Kharmawlong, George Kupar,Rani, Jims World Star,Rahman, Noimur,Dutta, Arup,Nongkhlaw, Rishanlang
, p. 2873. (2019/08/26)
The development of a metal-free protocol for transformations in organic synthesis offers a significant potential environmental benefit. This article reports the exploration of meglumine, a nontoxic and biodegradable amino sugar, as an organocatalyst for the synthesis of biologically active 1H-dibenzo[b,e][1,4]diazepin-1-ones, highly regioselective benzimidazole derivatives and derivatives of quinoxalines. Operational simplicity, mild reaction conditions, shorter reaction times, and use of green solvents are the highlights of this protocol. The advantage of ultrasonic irradiation has been significantly explored for the synthesis of the aforesaid compounds. Furthermore, the multifaceted use of o-phenylenediamine has also been accentuated in the study.
Microwave-assisted synthesis of 11-substituted-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one derivatives catalysed by silica supported fluoroboric acid as potent antioxidant and anxiolytic agents
Bhagat, Kavita,Singh, Atamjit,Dhiman, Suruchi,Vir Singh, Jatinder,Kaur, Ramandeep,Kaur, Gurinder,Kaur Gulati, Harmandeep,Singh, Palwinder,Kumar, Raman,Salwan, Rajan,Bhagat, Kajal,Singh, Harbinder,Sharma, Sahil,Singh Bedi, Preet Mohinder
, p. 2200 - 2217 (2019/11/03)
Keeping in view the successive attributes of benzodiazepines on the central nervous system, we have synthesized a novel series of benzodiazepine derivatives as antioxidant and anxiolytic agents. All the compounds were obtained in good yield by facile synt
Ultrasound assisted 1,4-diazabicyclo[2.2.2]octaniumdiacetate multicomponent synthesis of benzodiazepines: A novel, highly efficientand green protocol
Sarhandi, Shahriar,Fekri, Leila Zare,Vessally, Esmail
, p. 246 - 252 (2018/03/30)
A simple and efficient method is presented for the synthesis of benzodiazepines through the multicomponent reaction of α-phenylenediamine, various aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of the acidic bis ionic liquid 1,4-diazabicyclo[2.2.2]octanium diacetate under ultrasound irradiation. The ionic liquid used is recoverable and reusable. This procedure is simple and environmentally friendly, and offers easy work-up, mild conditions and excellent yield in a short reaction time. All of the synthesized compounds were characterized by IR, 1H NMR, mass spectrometry and elemental analysis.
Silica-supported NiO nanocomposites prepared: Via a sol-gel technique and their excellent catalytic performance for one-pot multicomponent synthesis of benzodiazepine derivatives under microwave irradiation
Nasir, Zeba,Ali, Abad,Shakir, Mohammad,Wahab, Rizwan,Shamsuzzaman,Lutfullah
, p. 5893 - 5903 (2017/07/11)
Heterogeneous and versatile NiO-SiO2 NCs were synthesized by a sol-gel technique and used as a catalyst for the one-pot multicomponent synthesis of benzodiazepine derivatives (4a-u) from a mixture of o-phenylenediamine, aromatic aldehydes and d
An efficient, environmentally benign, and solvent-free protocol for the synthesis of 4-substituted 1,5-benzodiazepines catalyzed by reusable sulfated polyborate
Indalkar, Krishna S.,Patil, Manisha S.,Chaturbhuj, Ganesh U.
supporting information, p. 4496 - 4502 (2017/11/03)
An efficient and environmentally benign method has been developed for the one-pot solvent-free synthesis of 4-substituted-1,5-benzodiazepines via three-component reaction of o-phenylenediamine, dimedone with a variety of aldehydes catalyzed by sulfated po
Practical carbocatalysis by graphene oxide nanosheets in aqueous medium towards the synthesis of diversified dibenzo[1,4]diazepine scaffolds
Kausar, Nazia,Mukherjee, Prasun,Das, Asish R.
, p. 88904 - 88910 (2016/09/28)
GO nanosheets are found to be an efficient recyclable carbocatalyst for the construction of diversified dibenzo[1,4]diazepine nuclei starting from o-phenylenediamine, various aldehyde/ketone and 1,3-diketo compounds in aqueous medium. This new metal free
Deep eutectic solvent as a highly efficient reaction media for the one-pot synthesis of benzo-fused seven-membered heterocycles
Shaabani, Ahmad,Hooshmand, Seyyed Emad,Nazeri, Mohammad Taghi,Afshari, Ronak,Ghasemi, Shima
supporting information, p. 3727 - 3730 (2016/07/26)
The combination of choline chloride and urea as a deep eutectic solvent has been applied to the synthesis of benzo-fused seven-membered heterocycles, including tricyclic 1,4-benzodiazepines and 1,4-benzoxazepines, via a one-pot, three-component reaction. The reaction conditions are relatively mild and do not require additional metals, acid catalysts, or organic solvents. The protocol has the advantages of excellent yields in short reaction times, an easy workup procedure, and being environmentally friendly.
