82419-52-1

Usage

Uses

Used in Pharmaceutical Industry:
OFLOXACIN RELATED COMPOUND A (25 MG) ((RS)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-10-(PIPERA-ZIN-1 -YL)-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID) is used as an impurity in the synthesis and manufacturing process of Ofloxacin, a widely used fluoroquinolone antibiotic. It plays a crucial role in ensuring the quality, safety, and efficacy of the final drug product by serving as a reference compound for quality control and regulatory compliance.
Additionally, as a metabolite of Ofloxacin, it may also be used in research and development for understanding the pharmacokinetics, metabolism, and potential side effects of the parent drug, Ofloxacin. This knowledge can contribute to the optimization of drug formulations, dosing regimens, and the development of new antimicrobial agents with improved safety and efficacy profiles.

Upstream product

• 110-85-0 piperazine 
• 82419-35-0 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid 
• 82419-36-1 ofloxacin 
• 86760-99-8 diethyl [(-)-7,8-difluoro-3-methyl-2,3-dihydro-4H-[1,4]benzoxazin-4-yl]methylenemalonate 
• 82419-33-8 (-)-7,8-difluoro-2,3-dihydro-3-methyl-4H-1,4-benzoxazine 
• 82419-34-9 ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate 
• 82419-26-9 2,3-difluoro-6-nitrophenol 
• 82419-32-7 3,4-difluoro-2-(2-oxopropyloxy)nitrobenzene 
• 771-69-7 2,3,4-trifluoronitrobenzene 

Downstream Products

• 1196096-84-0 8-fluoro-9-[4-(4-fluorophenylsulfonyl)piperazin-1-yl]-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 1196096-89-5 8-fluoro-9-[4-(4-fluorobenzoyl)piperazin-1-yl]-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 1196096-88-4 9-[4-benzoylpiperazin-1-yl]-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 1196096-94-2 8-fluoro-3-methyl-9-[4-(4-methoxybenzoyl)piperazin-1-yl]-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 1196096-91-9 8-fluoro-3-methyl-9-[4-(4-nitrobenzoyl)piperazin-1-yl]-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 1196096-81-7 8-fluoro-3-methyl-6-oxo-9-[4-(phenylsulfonyl)piperazin-1-yl]-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 1196096-87-3 8-fluoro-9-[4-(4-nitrophenylsulfonyl)piperazin-1-yl]-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 341004-76-0 8-fluoro-3-methyl-9-[4-(4-nitrophenylsulfonyl)piperazin-1-yl]-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 1351976-07-2 C₂₉H₂₃F₆N₃O₁₀ 

Relevant academic research and scientific papers

Nano-Fe3 O4@ZrO2-SO3 H as highly efficient recyclable catalyst for the green synthesis of fluoroquinolones

Nano-Fe3 O4 @ZrO2-SO3 H (n-FZSA), was utilized as a magnetic catalyst for the synthesis of various fluoroquinolone compounds. These compounds were prepared by the direct amination of 7-halo-6-fluoroquinolone-3-carboxylic acids with piperazine derivatives and (4aR,7aR)-octahydro-1H-pyrrolo[3,4-b] pyridine in water. The results showed that n-FZSA exhibited high catalytic activity towards the synthesis of fluoroquinolone derivatives, giving the desired products in high yields. Furthermore, the catalyst was recyclable and could be used at least seven times without any discernible loss in its catalytic activity. Overall, this new catalytic method for the synthesis of fluoroquinolone derivatives provides rapid access to the desired compounds in refluxing water following a simple work-up procedure, and avoids the use of organic solvents.

Facile synthesis of carbon quantum dots loaded with mesoporous g-C3N4 for synergistic absorption and visible light photodegradation of fluoroquinolone antibiotics

The development of facile and efficient synthetic approaches of carbon quantum dots loaded with mesoporous g-C3N4 (mpg-C3N4/CQDs) is of critical urgency. Here, a facile strategy was developed to synthesize the mpg-C3N4/CQDs by using calcinations of the mixture of CQDs, cyanamide, and silica colloid. The obtained composite still retained a considerable total surface area, which could offer a larger population of adsorption sites; therefore enhance the capacity for the adsorption of fluoroquinolones antibiotics (FQs). Under visible light irradiation, mpg-C3N4/CQDs demonstrated a higher photocatalytic activity for FQs degradation than did bulk g-C3N4 or mpg-C3N4. This enhancement might have been ascribed to the high surface area of the mpg-C3N4, unique up-converted photoluminescence (PL) properties, and the efficient charge separation of the CQDs. The eradication of FQs followed the Langmuir-Hinshelwood (L-H) kinetic degradation model and absorption pseudo-second-order kinetic model, indicating that surface reactions and chemical sorption played significant roles during the photocatalysis process. The results of electron spin resonance (ESR) technology and reactive species (RSs) scavenging experiments revealed that the superoxide anion radical (O2-) and photo-hole (h+) were the primarily active species that initiated the degradation of FQs. Based on the identification of intermediates and the prediction of reactive sites, the degradation pathways of ofloxacin (OFX) were proposed. A residual antibiotic activity experiment revealed that mpg-C3N4/CQDs provided very desirable performance for the reduction of antibiotic activity.

Conventional and microwave-assisted synthesis of quinolone carboxylic acid derivatives

Various antibacterial fluoroquinolone compounds are synthesized by the direct amination of 7-halo-6-fluoroquinolone-3-carboxylic acids with a variety of piperazine derivatives and (4aR,7aR)-octahydro-1H-pyrrolo[3,4-b]pyridine using microwave under different reaction conditions. Solvent free high yield microwave synthesis of antibacterial fluoroquinolone compounds is convenient, rapid and environmentally friendly method.

Synthesis and biological properties of conjugates between fluoroquinolones and a N3′′-functionalized pyochelin

Pyochelin is a siderophore common to Pseudomonas aeruginosa and several other pathogenic bacteria. A pyochelin functionalized at the N3′′ position with a propyl-amine extension was previously synthesized. In the present work we proved that this analog bin

Microwave assisted amination of quinolone carboxylic acids: An expeditious synthesis of fluoroquinolone antibacterials

A facile amination of quinolone carboxylic acids to fluoroquinolone antibacterials under microwave irradiation is described.

Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids

As part of a search for new synthetic antibacterial agents to combat systemic infection, various analogues of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids were synthesized. Among the compounds newly synthesized, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[ 1,2,3-de][1,4]benzoxazine-6-carboxylic acid (DL-8280) showed potent antibacterial activity against Gram-positive and -negative pathogens, including Psedomonas aeruginosa, and its metabolic disposition was shown in separate experimentals to be favorable.