82420-76-6

Upstream product

• 70-11-1 α-bromoacetophenone 
• 91-60-1 2-Naphthalenethiol 
• 36452-23-0 N-(phenylthio)-ε-caprolactam 
• 93-08-3 methyl 2-naphthyl ketone 
• 39689-37-7 sodium salt of β-mercaptonaphthalene 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 98-88-4 benzoyl chloride 
• 1021-45-0 phosphoric acid diethyl ester-(1-phenyl-vinyl ester) 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 882430-07-1 (R)-2-naphthyl phenacyl sulfoxide 
• 38226-58-3 2-(naphthalen-2-ylsulfinyl)-1-phenylethan-1-one 
• 158752-55-7 2-(naphthalen-2-ylsulfonyl)-1-phenylethan-1-one 
• 1248588-16-0 3-ethoxy-2-[(naphthalen-2-yl)sulfanyl]-1-phenylprop-2-en-1-one 
• 1046758-78-4 2,2-difluoro-2-(naphthalen-2-ylsulfonyl)-1-phenylethan-1-one 
• 7381-78-4 1-phenyl-1-(α-naphthyl)ethane 
• 36707-32-1 1-(1-naphthyl)-2-phenylethane 
• 101722-95-6 2-(phenyl)-β-hydroxyethyl 2-napthyl sulfide 
• 16587-59-0 3-phenylnaphtho[2,1-b]thiophene 
• 16587-38-5 2-phenylnaphtho<2,1-b>thiophene 

Relevant academic research and scientific papers

Catalyst-Free Difunctionalization of Activated Alkenes in Water: Efficient Synthesis of β-Keto Sulfides and Sulfones

Difunctionalization of activated alkenes, a powerful strategy in chemical synthesis, has been accomplished for direct synthesis of a series of β-keto sulfides and β-keto sulfones. The transformation, mediated by O2, proceeds smoothly in water and without any catalyst. Prominent advantages of this method include mild reaction conditions, purification simplicity, and gram-scale synthesis, underlining the practical utility of this methodology.

Catalyst-Free Insertion of Sulfoxonium Ylides into Aryl Thiols. A Direct Preparation of β-Keto Thioethers

Insertion of sulfoxonium ylides into the S-H bond of aryl thiols without the need for a catalyst is demonstrated, furnishing β-keto thioethers in excellent yield in most cases. The method overcomes traditional syntheses that employ metal catalysts in combination with diazo compounds or toxic and hard-prepared haloketones. The experimental setup consists of mixing the reagents in acetonitrile at room temperature. Additional experimental as well as kinetic isotopic effect studies give some insight into the mechanism of this reaction.

Regioselective synthesis of 5-(arylsulfanyl)- and 5-(benzylsulfanyl)-6- phenylsalicylates by one-pot cyclizations of 1,3-bis(silyloxy)buta-1,3-dienes with 2-(arylsulfanyl)- and 5-(benzylsulfanyl)-3-ethoxy-1-phenylprop-2-en-1-ones

5-(Arylsulfanyl)-6-phenylsalicylates were prepared by one-pot cyclizations of 1,3-bis(trimethylsilyloxy) buta-1,3-dienes with 2-(arylsulfanyl)-3-ethoxy-1- phenylprop-2-en-1-ones.

An efficient fluorination of β-ketosulfones promoted by a room-temperature ionic liquid at ambient conditions under ultrasound irradiation using Selectfluor F-TEDA-BF4

The fluorination reaction involving a β-ketosulfones by Selectfluor was efficiently promoted by the ionic liquid, [Hbim]BF4 (IL) as a reaction medium with methanol as co-solvent at room temperature under ultrasonic irradiation to afford the corresponding mono and difluoro-β-ketosulfones in excellent yields. The advantages of this method include among others the use of a recyclable, non-volatile ionic liquid, which promotes this protocol under room temperature without the requirement of any added catalyst under ultrasonic irradiation.

α-Fluorination of β-ketosulfones by Selectfluor F-TEDA-BF4

Attempted fluorination of β-ketosulfides using Selectfluor resulted only in the isolation of the corresponding diaryl disulfides, presumed to arise by decomposition of an unstable fluorinated intermediate. However, fluorination of β-ketosulfones using Selectfluor under anhydrous conditions does allow the isolation of both mono-and difluorinated products in moderate to good yields.

The synthesis of chiral β-ketosulfoxides by enantioselective oxidation and their stereocontrolled reduction to β-hydroxysulfoxides

Various chiral non-racemic β-ketosulfoxides, a class of compounds frequently used in asymmetric synthesis, were prepared in good yields by tert-butyl hydroperoxide oxidation of the corresponding sulfides in the presence of a complex between titanium and (

A novel reaction of N-phenylthiocaprolactam: The α-sulfenylation of ketones under mild conditions

N-phenylthiocaprolactam (2) reacts with the enolate anions of aliphatic, aromatic or cyclic ketone 1a-e, to give the corresponding α-phenylthioketones 3a-e. This reaction proceeds with high yields of monosulphenylation (80-97%) in DMSO under mild conditions (potassium ter-butoxide, 25°C, 10 min).