82463-70-5

Upstream product

• 55100-33-9 N-methyl-3,4,5-trimethoxybenzamide 
• 70242-11-4 2-bromo-3,4,5-trimethoxy-benzoyl chloride 
• 74-89-5 methylamine 
• 118-41-2 Eudesmic acid 
• 23346-82-9 2-bromo-3,4,5-trimethoxybenzoic acid 

Downstream Products

• 23434-97-1 thalactamine 
• 73232-34-5 5,6,7-trimethoxy-2,3-dimethyl-1(2H)-isoquinolone 
• 55100-33-9 N-methyl-3,4,5-trimethoxybenzamide 

Relevant academic research and scientific papers

A versatile approach to 1-oxo-, 1-oxo-3,4-dihydro- and 1,3,4-trioxo isoquinoline alkaloids and first total synthesis of the dimeric 1-oxoisoquinoline alkaloids berbanine and berbidine

We have worked out a very short approach to 1-oxoisoquinoline alkaloids starting from readily available 2-bromobenzamides utilizing a 2-ethoxyvinylboronate as a C2 building block for introduction of the C-3,C-4 unit of the isoquinoline core. TF

Room-temperature debenzylation of N-benzylcarboxamides by N-bromosuccinimide

A simple and highly efficient method has been developed with which to cleave the N-benzyl group on N-mono- or disubstituted carboxamides using N-bromosuccinimide (NBS) at room temperature. All the 31 substrates examined showed moderate to excellent deprotection yields. Our study also indicated that the debenzylation may involve an oxygen/light initiated free radical mechanism. Georg Thieme Verlag Stuttgart.

Studies on SRN1 Reactions. Part 6: Synthesis of 3-Methyl Derivatives of the Alkaloids Thalactamine, Doryanine, and 6,7-Dimethoxy-N-methyl-1(2H)-isoquinolone

A new, short synthesis of the 3-methyl derivatives (3a-c) of the alkaloids thalactamine, doryanine, and 6,7-dimethoxy-N-methyl-1(2H)-isoquinolone, based upon our previous SRN1 synthesis of isocarbostryril systems, is reported.