55100-33-9

Usage

Uses

Used in Pharmaceutical Research:
3,4,5-trimethoxy-N-methylbenzamide is used as a potential drug candidate for various therapeutic applications in pharmaceutical research. Its unique molecular structure with methoxy and amide groups contributes to its potential pharmacological properties, making it a promising compound for the development of new drugs.
Used in Medicinal Chemistry:
3,4,5-trimethoxy-N-methylbenzamide is used in medicinal chemistry for the investigation and development of its potential biological activities. Its unique molecular structure may offer insights into the treatment of certain diseases or medical conditions, providing a valuable resource for the discovery of new therapeutic agents.

Upstream product

• 82463-70-5 2-bromo-3,4,5-trimethoxy-N-methylbenzamide 
• 67-64-1 acetone 
• 74-89-5 methylamine 
• 118-41-2 Eudesmic acid 
• 421-20-5 Methyl fluorosulfonate 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 23346-82-9 2-bromo-3,4,5-trimethoxybenzoic acid 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 3086-62-2 3,4,5-trimethoxybenzamide 
• 67-56-1 methanol 
• 39201-89-3 3,4,5-trimethoxybenzaldehyde oxime 

Downstream Products

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 18638-99-8 3,4,5-trimethoxybenzylamine 
• 82791-57-9 6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxy-phenyl)-2H-isoquinolin-3-one 
• 82463-70-5 2-bromo-3,4,5-trimethoxy-N-methylbenzamide 
• 58780-82-8 N-methyl-1-(3,4,5-trimethoxyphenyl)methanamine 

Relevant academic research and scientific papers

Rhodium-Catalyzed Electrooxidative C?H Olefination of Benzamides

Metal-catalyzed chelation-assisted C?H olefinations have emerged as powerful tools for the construction of functionalized alkenes. Herein, we describe the rhoda-electrocatalyzed C?H activation/alkenylation of arenes. The olefinations of challenging electron-poor benzamides were thus accomplished in a fully dehydrogenative fashion under electrochemical conditions, avoiding stoichiometric chemical oxidants, and with H2 as the only byproduct. This versatile alkenylation reaction also features broad substrate scope and used electricity as a green oxidant.

Ruthenium-Catalyzed Synthesis of N-Methylated Amides using Methanol

An efficient synthesis of N-methylated amides using methanol in the presence of a ruthenium(II) catalyst is realized. Notably, applying this process, tandem C-methylation and N-methylation were achieved to synthesize α-methyl N-methylated amides. In addition, several kinetic studies and control experiments with the plausible intermediates were performed to understand this novel protocol. Furthermore, detailed computational studies were carried out to understand the mechanism of this transformation.

Chemoselective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage under Catalyst-Free Conditions

Conversion of a wide range of N-Boc amides to aryl ketones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage. The reactions proceeded under catalyst-free conditions with different aryl, alkyl, and alkynyl Grignard reagents. α-Ketoamide was successfully converted to aryl diketones, while α,β-unsaturated amide underwent 1,4-addition followed by C(O)-N bond cleavage to provide diaryl propiophenones. N-Boc amides displayed higher reactivity than Weinreb amides with Grignard reagents. A broad substrate scope, excellent yields, and quick conversion are important features of this methodology.

Tandem Transformation of Aldoximes to N-Methylated Amides Using Methanol

Tandem conversion of aldoximes to N-methylated amides with methanol in presence of a single Ru(II) catalyst is accomplished through the Ru(II)-mediated rearrangement followed by the reductive N-methylation. Employing this protocol, several aldoximes were directly transformed to the N-methylated amides using methanol. Kinetic experiments with H218O advocated that the aldoxime is acted as the nucleophile during the aldoxime to amide rearrangement process. Involvement of nitrile intermediate during this transformation is realized from the kinetic study. (Figure presented.).

Atom-Economical and Tandem Conversion of Nitriles to N-Methylated Amides Using Methanol and Water

A cobalt complex catalyzed tandem conversion of nitrile to N-methylated amide is described using a methanol and water mixture. Using this protocol, several nitriles were directly and efficiently converted to the desired N-methylated amides. Kinetic experiments using H2O18 and CD3OD suggested that water and methanol were the source of the oxygen atom and methyl group, respectively, in the final N-methylated amides. Importantly, the participation of active Co(I)-H species in this transformation was realized from the control experiment. The kinetic isotope effect (KIE) study suggested that the activation of the C-H bond of methanol was a kinetically important step. The Hammett plot confirmed that the reaction was faster with the electron deficient nitriles. In addition, the plausible pathway for the formation of N-methylated amides from the nitriles was supported by the computational study.

Metal-free aryltrifluoromethylation of activated alkenes

Metal-free: The first metal-free aryltrifluoromethylation of activated alkenes has been developed. With this method, trifluoromethylated isoquinolinediones, spirobicycles, oxindoles, and α-aryl-β- trifluoromethylamides were obtained with high control of the regioselectivity. Copyright

Copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagents

The copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagent are described. Various amides and carboxylic acids were methylated affording N-substituted amides and esters. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.

N-methylation of substituted benzonitriles with methyl fluorosulfonate

Substituted benzonitriles ArCN treated at 20-70°C with methyl fluorosulfonate yield the corresponding N-methylbenzamides ArCONHMe. Compounds with two cyano groups afford N,N′-methylated diamides.

SUBSTITUTED PIPERAZINE DERIVATIVES

The present invention relates to substituted piperazine derivatives (herein referred to as compounds or compounds of formula (1)) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagon

Substituted alkyldiamine derivatives

The present invention relates to novel substituted alkyldiamine derivatives and pharmaceutically acceptable salts thereof which are useful tachykinin antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions including asthma, cough, and bronchitis.