82493-60-5Relevant articles and documents
Use of the Two Enantiometers of 7,7-Dimethylbicyclohept-2-en-6-one to form Complementary Optically Active Synthons in a Convergent Synthesis of Leukotriene-B4
Cotterill, Ian C.,Jaouhari, Rabih,Dorman, Gyoergy,Roberts, Stanley M.,Scheinmann, Feodor,Wakefield, Basil J.
, p. 2505 - 2512 (2007/10/02)
The acetate (+/-)-4 was resolved by an enantioselective hydrolysis catalysed by porcine pancreatic lipase.The resultant alcohol (-)-3 and the optically active ester (+)-4 were converted into the ketones (+)-2 and (-)-2 respectively.The ketone (+)-2 was el
STEREOSPECIFIC SYNTHESIS OF LEUKOTRIENE B4 (LTB4)
Guindon, Yvan,Zamboni, Robert,Cheuk-Kun Lau,Rokach, Joshua
, p. 739 - 742 (2007/10/02)
A stereospecific and chirally economical synthesis of LTB4 starting from 2-deoxy-D-ribose is reported as part of a comprehensive and efficient approach to the Leukotrienes (A, B, C, D, E).The process includes a novel approach to chiral dienic synthons.