82707-05-9Relevant articles and documents
Total synthesis of soraphen A(1α)
Abel, Stephan,Faber, Dominik,Hueter, Ottmar,Giese, Bernd
, p. 188 - 197 (2007/10/03)
The convergent synthesis of macrolide soraphen A(1α) is described starting from glucose (western part) and mannose (eastern part). Mannose was converted into a 2-deoxyribohexopyranoside that could be methylated and reduced stereoselectively. Chain elongation at C-6 was carried out by stereoselective addition of a magnesium acctylide. The two fragments (western and eastern) were assembled by a Julia olefination followed by macrolactonization. The introduction of the methyl group at C-2 of norsoraphen occurred stereoselectively for thermodynamic reasons.
THE OXIRANE RING OPENINGS OF THE DIANHYDRO SUGAR WITH HIGH REGIOSELETIVITY AND ITS USE IN PREPARATION OF TWO CHIRAL SEGMENTS OF 6-DEOXYERYTHRONOLIDE B
Wakamatsu, Takeshi,Nakamura, Hideo,Nishimiki, Yuji,Yoshida, Kaoru,Noda, Tomoko,Taniguchi, Masato
, p. 6071 - 6074 (2007/10/02)
The oxirane ring of the dianhydro sugar 2 obtained from levoglucosan (1,6-anhydro-β-D-glucose) is opened regioselectively with organometallic carbon nucleophiles and its application to an asymmetric synthesis of the C1-C5 segment 9 t
ASSEMBLY OF THE C19-C29 ALIPHATIC SEGMENT OF RIFAMYCIN S FROM D-DLUCOSE BY THE CHIRON APPROACH
Hanessian, Stephen,Pougny, Jean-Rene,Boessenkool, Ideletta K.
, p. 1289 - 1302 (2007/10/02)
We describe a stereocontrolled method for the construction of the aliphatic chain of rifamycin S, based on a strategy that utilizes carbohydrates as optically active precursors.