82755-72-4Relevant academic research and scientific papers
Method for decarboxylation generation C-S key of active ester compound
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Paragraph 0029-0035, (2021/09/21)
To an aspect of the present invention, there is provided a method of decarboxylation-generating C-S bonds by using an active ester compound in which the general formula is R under light irradiation. a Active ester of - COONPhth and general form
Visible-light induced decarboxylative coupling of redox-active esters with disulfides to construct C-S bonds
Xiao, Zhiwei,Wang, Lu,Wei, Junjie,Ran, Chongzhao,Liang, Steven H.,Shang, Jingjie,Chen, Guang-Ying,Zheng, Chao
, p. 4164 - 4167 (2020/04/22)
A novel method has been established for the construction of C-S bonds using redox-active esters with disulfides in the presence of Ru-photoredox catalyst. This method exhibits remarkable functional group tolerance across a wide scope of substrates. Under
Process for alkylation of group VI compound
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Paragraph 0033-0046, (2020/07/15)
The invention provides a process for alkylation of a group VI compound. Under an illumination condition, an active ester with a general formula of Ra-COONPhth and a main group VI compound with a general formula of Rb-A-Rc undergo the following reaction un
Iron-Catalysed Remote C(sp3)?H Azidation of O-Acyl Oximes and N-Acyloxy Imidates Enabled by 1,5-Hydrogen Atom Transfer of Iminyl and Imidate Radicals: Synthesis of γ-Azido Ketones and β-Azido Alcohols
Torres-Ochoa, Rubén O.,Leclair, Alexandre,Wang, Qian,Zhu, Jieping
supporting information, p. 9477 - 9484 (2019/05/21)
In the presence of a catalytic amount of iron(III) acetylacetonate [Fe(acac)3], the reaction of structurally diverse ketoxime esters with trimethylsilyl azide (TMSN3) afforded γ-azido ketones in good to excellent yields. This unprecedented distal γ-C(sp3)?H bond azidation reaction went through a sequence of reductive generation of an iminyl radical, 1,5-hydrogen atom transfer (1,5-HAT) and iron-mediated redox azido transfer to the translocated carbon radical. TMSN3 served not only as a nitrogen source to functionalise the unactivated C(sp3)?H bond, but also as a reductant to generate the catalytically active FeII species in situ. Based on the same principle, a novel β-C(sp3)?H functionalisation of alcohols via N-acyloxy imidates was subsequently realised, leading, after hydrolysis of the resulting ester, to β-azido alcohols, which are important building blocks in organic and medicinal chemistry.
Manganese-catalyzed regiospecific sp3 C-S bond formation through C-C bond cleavage of cyclobutanols
Ren, Rongguo,Wu, Zhen,Zhu, Chen
supporting information, p. 8160 - 8163 (2016/07/06)
A manganese-catalyzed regioselective sp3 C-S bond formation through C-C bond cleavage of cyclobutanols is described. A variety of primary and secondary alkyl thioethers are efficiently prepared under mild reaction conditions. The mechanistic pathways involving radical-mediated tandem C-C bond cleavage and C-S bond formation are proposed.
Preparation and reactivity of polyfunctional zinc and copper organometallics bearing sulfur functionalities
Achyutha Rao,Chou, Tso-Sheng,Schipor, Ioana,Knochel, Paul
, p. 2025 - 2043 (2007/10/02)
Iodomethylthiobenzoate 5 and α-chloroalkyl phenyl sulfides 6 were found to insert zinc dust in THF under very mild conditions (10-25°C, 0.5-2 h) leading to zinc α-thioorganometallics. After a transmetallation with CuCN·2 LiCl, the corresponding copper rea
Benzylketone phospholipase A2 inhibitors
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, (2008/06/13)
The invention relates to benzylketone phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2 -mediated conditions in mammals by administration of a therapeutically effective
BENZYLKETONE PHOSPHOLIPASE A2 INHIBITORS
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, (2008/06/13)
The invention relates to benzylketone phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2 -mediated conditions in mammals by administration of a therapeutically effective amount of such a benz
Preparation of Functionalized Zinc and Copper Organometallics Containing Sulfur Functionalities at the Alpha or Gamma Position
Rao, Sidduri Achyutha,Tucker, Charles E.,Knochel, Paul
, p. 7575 - 7578 (2007/10/02)
α-Chloroalkyl phenyl sulfides 1 readily insert zinc in THF at 25 deg C (0.5-2 h), affording sulfur stabilized organozinc derivatives of type 2.The presence of a functional group such as an ester or a cyano group is tolerated in these organometallics.After a transmetallation to the corresponding copper reagent 3, they react with a wide range of electrophiles.Zinc and copper organometallics bearing a thiophenyl or a phenylsulfinyl group at the γ-position have also been prepared showing the generality of our approach.
Intramolecular Charge-Transfer Interactions in Triplet Keto Sulfides
Wagner, Peter J.,Lindstrom, Michael J.
, p. 3057 - 3062 (2007/10/02)
The photochemistry of β-,γ-and δ-phenacyl sulfides, sulfoxides, and sulfones has been studied.The first group undergoes no irreversible reaction.The other two undergo type II photoelimination but in low quantum efficiency.Analysis of triplet lifetimes and product quantum yields indicates that all undergo rapid internal quenching, which is ascribed to a charge-transfer (CT) process.The positional dependence of rate constants for this CT reaction is β > γ > α >> δ > ε .Some rate constants (units of 1E8 s-1) for PhCO(CH2)nSBu are as follows: n = 1, 16; n = 2, 55; n = 3, 29; n = 4 ,1.7; n = 5, PhS BuS(O) >> BuS, BuSO2, CH3CO-S and range from 1E9-3*1E5 s-1.Rate constants for triplet state γ-hydrogen abstraction were found to correlate well with the ?1 values of the various sulfur groups, except for δ-sulfinyl, which apparently participates in the reaction.
