82922-13-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(Ethylamino)-2-methyl-1-propanol(SALTDATA: HCl) is used as an antiarrhythmic agent for its ability to suppress abnormal heart rhythms in animals. Its stovaine analog function also contributes to its potential use in the development of medications for cardiac conditions.
Additionally, due to its unique chemical structure and properties, 2-(ethylamino)-2-methyl-1-propanol(SALTDATA: HCl) may be utilized in various other applications within the pharmaceutical industry, such as a precursor in the synthesis of other bioactive compounds or as a component in drug formulations. However, further research and development would be required to explore and validate these potential uses.

Upstream product

• 74-96-4 ethyl bromide 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 1772-43-6 2,4,4-trimethyl oxazoline 
• 75-03-6 ethyl iodide 

Downstream Products

• 25688-63-5 2-(diethylamino)-2-methylpropan-1-ol 
• 69781-16-4 4-amino-benzoic acid-(β-ethylamino-isobutyl ester); hydrochloride 
• 50-00-0 formaldehyd 
• 75-04-7 ethylamine 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 75-07-0 acetaldehyde 
• 67-64-1 acetone 
• 69781-14-2 3-amino-benzoic acid-(β-ethylamino-isobutyl ester) 

Relevant academic research and scientific papers

Transfer Hydrogenation of Cyclopamine Analogs

Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.

IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS

In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or Aurora kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or Aurora kinases using such compounds or pharmaceutical compositions.

N-Alkyl-5,5-dimethyl-2-oxomorpholin-3-yl radicals. Characterization and reaction with molecular oxygen

The synthesis of bi(4,5,5-trimethyl-2-oxomorpholin-3-yl) (TM-3′ dimer), bi(5,5-dimethyl-4-cthyl-2-oxomorpholin-3-yl) (DEM-3 dimer), and bi(5,5-dimethyl-4-isopropyl-2-oxomorpholin-3-yl) (DIM-3 dimer) by one-electron oxidation of 4,5,5-trimethyl-2-oxomorpholine (8), 5,5-dimethyl-4-ethyl-2-oxomorpholine (9), and 5,5-dimethyl-4-isopropyl-2-oxomorpholine (10), respectively, with photochemically generated rert-butoxyl radical is described. dl-TM-3′ dimer, meso-DEM-3 dimer, and meso-DIM-3 dimer were characterized from spectra and by X-ray crystallography. In solution the radical dimers existed in equilibrium with the captodatively substituted radicals, 4,5,5-trimethyl-2-oxomorpholin-3-yl (TM-3′), 5,5-dimethyl-4-ethyl-2-oxomorpholin-3-yl (DEM-3), and 5,5-dimethyl-4-isopropyl-2-oxomorpholin-3-yl (DIM-3), respectively, as indicated by EPR spectroscopy. The activation parameters for bond homolysis in ethanol solvent were measured by oxidatively trapping the radicals with diphenylpicrylhydrazyl (DPPH). The half-lives for bond homolysis vary by S orders of magnitude at 25°C with a value of only 2.3 s for DIM-3 dimer. DIM-3 dimer reacted quantitatively with molecular oxygen to form a mixture of meso- and dl-bis(5,5-dimethyl-4-isopropyl-2-oxomorpholin-3-yl) peroxides (DIM-3 peroxides), which were isolated and characterized spectroscopically and analytically. At ambient temperature the peroxides fragmented by C-O bond homolysis to release the DIM-3 radical as indicated by EPR spectroscopy and were solvolyzed by protic solvent with release of hydrogen peroxide. The solvolysis was reversed by evaporation of the protic solvent, which restored most of the DIM-3 peroxides. The peroxides also slowly fragmented irreversibly to 5,5-dimethyl-3-hydroxy-4-isopropyl-2-oxomorpholine (21) and 5,5-dimethyl-2,3-dioxo-4-isopropylmorpholine (23) in polar aprotic solvent.