83022-73-5

Upstream product

• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 75-26-3 isopropyl bromide 

Downstream Products

• 55332-36-0 (S)-2-(4-methoxyphenyl)-3-methylbutyric acid 
• 88588-30-1 (2R)-2-(4-methoxyphenyl)-3-methylbutanoic acid 
• 111197-95-6 (S)-2-(4-Methoxy-phenyl)-3-methyl-butyric acid methyl ester 
• 83022-73-5 (R)-2-(4-Methoxy-phenyl)-3-methyl-butyric acid methyl ester 
• 1061284-74-9 C₁₆H₂₃BrO₃ 

Relevant academic research and scientific papers

Synthesis and evaluation of α,α′-disubstituted phenylacetate derivatives for T-type calcium channel blockers

We have synthesized and evaluated α,α′-disubstituted phenylacetate derivatives that were designed as T-type calcium channel blockers. Among them, compound 10e (IC50 = 8.17 ± 0.48 nM) showed the most potent T-type calcium current blocking activity and higher potency than Mibefradil (IC50 = 1.34 ± 0.49 μM). The PK profile and subtype selectivity over L-type calcium channel were satisfied for further animal assay using disease model.

ENZYMATIC RESOLUTION OF METHYL 2-ALKYL-2-ARYLACETATES

Horse liver esterase, used as its inexpensive commercial acetone powder, catalyzes the selective hydrolysis of methy 2-alkyl-2-arylacetates to afford R(-)-2-alkyl-2-arylacetic acids and S(+)-methyl 2-alkyl-2-arylacetates.