832735-61-2

Basic information

• Product Name: 5-bromo-1-(difluoromethyl)pyridin-2(1H)-one
• Synonyms: 5-bromo-1-(difluoromethyl)pyridin-2(1H)-one;5-Bromo-1-(difluoromethyl)pyridine-2(1H)-one;5-Bromo-1-difluoromethyl-1H-pyridin-2-one;2(1H)-Pyridinone,5-bromo-1-(difluoromethyl)-;5-Bromo-1-(difluoromethyl)
• CAS NO: 832735-61-2
• Molecular Formula: C6H4BrF2NO
• Molecular Weight: 224.0028664
• Mol File: 832735-61-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 74-76℃
• Boiling Point: 253℃
• Flash Point: 107℃
• Appearance: /
• Density: 1.821
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 5-bromo-1-(difluoromethyl)pyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-1-(difluoromethyl)pyridin-2(1H)-one(832735-61-2)
• EPA Substance Registry System: 5-bromo-1-(difluoromethyl)pyridin-2(1H)-one(832735-61-2)

Safety Data

• Hazardous Substances Data: 832735-61-2(Hazardous Substances Data)

Usage

General Description

5-bromo-1-(difluoromethyl)pyridin-2(1H)-one is a chemical compound with the molecular formula C6H3BrF2NO. It is a pyridinone derivative that contains a bromine atom and two fluorine atoms attached to a difluoromethyl group. 5-bromo-1-(difluoromethyl)pyridin-2(1H)-one is commonly used in the pharmaceutical and agrochemical industries for the synthesis of various biologically active molecules. 5-bromo-1-(difluoromethyl)pyridin-2(1H)-one has also been studied for its potential antiviral and antibacterial properties, making it a valuable target for drug discovery and development. Additionally, it can be used as a reagent in organic synthesis for the creation of new chemical compounds with diverse applications.

Upstream product

• 1198765-29-5 N-[(2E)-5-bromo-1-(difluoromethyl)pyridin-2(1H)-ylidene]acetamide 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 13466-38-1 5-bromopyridin-2(1H)-one 
• 7169-97-3 N-(5-bromopyridin-2-yl)acetamide 
• 2218-52-2 sodium salt of difluoroacetate 
• 13466-38-1 5-bromopyridin-2-ol 
• 76-04-0 2-chloro-2,2-difluoroacetic acid 
• 1072-97-5 5-bromo-2-pyridylamine 
• 1895-39-2 sodium chlorodifluoroacetate 
• 667-27-6 Ethyl bromodifluoroacetate 
• 766-11-0 5-bromo-2-fluoropyridine 
• 1717-59-5 2,2-difluoro-2-(fluorosulfonyl)acetic acid 
• 53939-30-3 5-bromo-2-chloropyridine 
• 899452-27-8 N-[5-bromo-1-(difluoromethyl)pyridin-2(1H)-ylidene]acetamide 

Downstream Products

• 1352152-41-0 1-(difluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2-one 

Relevant articles and documents

Chemoselective N- And O-Difluoromethylation of 2-Pyridones, Isoquinolinones, and Quinolinones with TMSCF2Br

An operationally simple protocol for direct N- and O-difluoromethylation of 2-pyridones, quinolinones, and isoquinolinones using commercially available TMSCF2Br is disclosed. The chemoselectivity is modulated by simple variations in temperature, solvent,

Substituted thiazole derivative and application thereof

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SUBSTITUTED N-[1-CYANO-2-(PHENYL)ETHYL] 1-AMINOCYCLOALK-1-YLCARBOXAMIDE COMPOUNDS - 760

The present invention provides compounds of formula (I) in which, n, R1, R2 and Q are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.