832735-61-2

Usage

Uses

Used in Pharmaceutical Industry:
5-bromo-1-(difluoromethyl)pyridin-2(1H)-one is used as a key intermediate in the synthesis of various biologically active molecules, including drugs with potential therapeutic applications. Its unique structural features, such as the bromine and fluorine atoms, contribute to its versatility in medicinal chemistry, allowing for the development of novel compounds with improved pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical industry, 5-bromo-1-(difluoromethyl)pyridin-2(1H)-one serves as a building block for the creation of new agrochemicals with enhanced pesticidal or herbicidal activities. Its chemical properties enable the design of molecules with improved selectivity, efficacy, and environmental compatibility, addressing the growing demand for sustainable agricultural practices.
Used in Antiviral and Antibacterial Drug Development:
5-bromo-1-(difluoromethyl)pyridin-2(1H)-one has been studied for its potential antiviral and antibacterial properties, making it a valuable target for drug discovery and development. Its ability to inhibit viral or bacterial replication can be harnessed to create new therapeutic agents for the treatment of infectious diseases, offering alternative solutions to existing treatments and addressing the issue of drug resistance.
Used as a Reagent in Organic Synthesis:
5-bromo-1-(difluoromethyl)pyridin-2(1H)-one can also be utilized as a reagent in organic synthesis for the creation of new chemical compounds with diverse applications. Its unique functional groups and reactivity make it a valuable component in the synthesis of various organic molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals, expanding its potential uses beyond its direct applications in drug discovery and development.

Upstream product

• 899452-28-9 5-bromo-1-(difluoromethyl)pyridin-2(1H)-imine 
• 899452-27-8 N-[5-bromo-1-(difluoromethyl)pyridin-2(1H)-ylidene]acetamide 
• 53939-30-3 5-bromo-2-chloropyridine 
• 1717-59-5 2,2-difluoro-2-(fluorosulfonyl)acetic acid 
• 766-11-0 5-bromo-2-fluoropyridine 
• 667-27-6 Ethyl bromodifluoroacetate 
• 13466-38-1 5-bromopyridin-2(1H)-one 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 1198765-29-5 N-[(2E)-5-bromo-1-(difluoromethyl)pyridin-2(1H)-ylidene]acetamide 
• 7169-97-3 N-(5-bromopyridin-2-yl)acetamide 
• 1072-97-5 5-bromo-2-pyridylamine 
• 13466-38-1 5-bromopyridin-2-ol 
• 76-04-0 2-chloro-2,2-difluoroacetic acid 
• 1895-39-2 sodium chlorodifluoroacetate 

Downstream Products

• 1352152-41-0 1-(difluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridin-2-one 

Relevant academic research and scientific papers

Chemoselective N- And O-Difluoromethylation of 2-Pyridones, Isoquinolinones, and Quinolinones with TMSCF2Br

An operationally simple protocol for direct N- and O-difluoromethylation of 2-pyridones, quinolinones, and isoquinolinones using commercially available TMSCF2Br is disclosed. The chemoselectivity is modulated by simple variations in temperature, solvent,

SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF

Provided herein are 2-amino-pyrazolyl-[ 1,2,4]triazolo [1,5a]pyridine derivatives. Such compounds are useful, for example, for the treatment and/or prevention of neurodegenerative diseases or disorders such as ophthalmological neurodegenerative disorders. This disclosure also features compositions containing the same as well as methods of using and making the same.

Substituted thiazole derivative and application thereof

The invention provides a compound represented by a general formula (I), or a stereoisomer, pharmaceutically acceptable salt, solvate, hydrate, chemically protective form or prodrug thereof. The compound has an effect of inhibiting adenosine receptor 2a (A2a), and can be used as an antagonist of the adenosine receptor 2a (A2A) for treating tumors.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

SUBSTITUTED N-[1-CYANO-2-(PHENYL)ETHYL] 1-AMINOCYCLOALK-1-YLCARBOXAMIDE COMPOUNDS - 760

The present invention provides compounds of formula (I) in which, n, R1, R2 and Q are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.

Inhibitors of Bruton's Tyrosine Kinase

This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-Phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-III: wherein, variables Q, R, X, X′, Y1, Y2, Y2′, Y3, Y4, Y5, m, and n are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.

Facile one-pot synthesis of N-difluoromethyl-2-pyridone derivatives

A novel one-pot synthesis of N-difluoromethyl-2-pyridones is described. N-(Pyridin-2-yl)acetamide derivatives were excellent precursors for the preparation of N-difluoromethyl-2-pyridone derivatives. Difluoromethylation of 2-acetaminopyridine derivatives was achieved with sodium chlorodifluoroacetate as a difluorocarbene source in the presence of a catalytic amount of 18-crown-6. Subsequent in situ hydrolysis of resultant 1,2-dihydro-2-acetimino-1- difluoromethylpyridines proceeded under mild acidic conditions to afford the corresponding N-difluoromethyl-2-pyridones in moderate to good yields.