83575-55-7

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 151-50-8 potassium cyanide 
• 1122-91-4 4-bromo-benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 83575-81-9 (4-Bromo-phenyl)-dimethylamino-trimethylsilanyloxy-acetonitrile 
• 6940-50-7 4-bromo-DL-mandelic acid 
• 97379-28-7 2-(4-bromophenyl)-2-hydroxy-1-(4-methoxyphenyl)-1-ethanone 
• 18469-37-9 4-bromo-N,N-dimethylbenzamide 
• 1566593-61-0 2-((4-bromobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 173596-62-8 α-fluoro(p-bromophenyl)acetonitrile 
• 127709-20-0 α-hydroxy-(p-bromophenyl)-acetic acid methyl ester 
• 150521-30-5 2-hydroxy-2-(4-bromophenyl)acetonitrile 
• 58289-69-3 2-(4-bromophenyl)-2-hydroxyacetonitrile 

Relevant academic research and scientific papers

The catalytic activity of Zn(II) and Mn(II) organometallic complexes

Zn(II) and Mn(II) organometallic complexes I and II were first used to catalyze the cyanosilylation reaction, and good catalytic results (24-99 %) were achieved. The catalytic activity of the complexes was determined by 1H NMR.

Cyanosilylation of carbonyl compounds catalyzed by half-sandwich (η6-p-cymene) Ruthenium(II) complexes bearing heterocyclic hydrazone derivatives

A new class of half-sandwich (?6-p-cymene) ruthenium(II) complexes supported by heterocyclic hydrazone derivatives of general formula [Ru(?6-p-cymene)(Cl)(L)] where L represents N’-((1H-pyrrol-2-yl)methylene)furan-2-carbohydrazide (L

Application of an Electrochemical Microflow Reactor for Cyanosilylation: Machine Learning-Assisted Exploration of Suitable Reaction Conditions for Semi-Large-Scale Synthesis

Cyanosilylation of carbonyl compounds provides protected cyanohydrins, which can be converted into many kinds of compounds such as amino alcohols, amides, esters, and carboxylic acids. In particular, the use of trimethylsilyl cyanide as the sole carbon source can avoid the need for more toxic inorganic cyanides. In this paper, we describe an electrochemically initiated cyanosilylation of carbonyl compounds and its application to a microflow reactor. Furthermore, to identify suitable reaction conditions, which reflect considerations beyond simply a high yield, we demonstrate machine learning-assisted optimization. Machine learning can be used to adjust the current and flow rate at the same time and identify the conditions needed to achieve the best productivity.

Silyl Cyanopalladate-Catalyzed Friedel-Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives

3-Aryloxindole derivatives were synthesized through a Friedel-Crafts-type cyclization. The reaction was catalyzed by a trimethylsilyl tricyanopalladate complex generated in situ from trimethylsilyl cyanide and Pd(OAc) 2. Wide varieties of diethyl phosphates derived from N -arylmandelamides were converted almost quantitatively into oxindoles. When N, N -dibenzylamide was used instead of an anilide substrate, a benzo-fused δ-lactam was obtained. An oxindole product was subjected to substitution reactions to afford 3,3-diaryloxindoles with two different aryl groups.

An uncoordinated tertiary nitrogen based tricarboxylate calcium network with Lewis acid-base dual catalytic sites for cyanosilylation of aldehydes

The design and utilization of dual sites for synergistic catalysts has been recognised as an efficient method towards high-efficiency catalysis in the cyanosilylation of aldehydes, which gives key intermediates for the synthesis of a number of valuable na

Organo-catalyzed Michael addition of 2-fluoro-2-arylacetonitriles

An efficient synthesis of a variety of 2-arylacetonitriles containing a fluorinated stereogenic center through organo-catalyzed Michael addition reaction of 2-fluoro-2-arylacetonitriles has been developed. This protocol uses a cheap organocatalyst (DBU) and has a broad substrate scope: α, β-unsaturated ketones, esters, nitriles and sulfones were all successfully reacted. Importantly, water proved to be a good solvent for this reaction.

Conjugated Bis-Guanidines (CBGs) as β-Diketimine Analogues: Synthesis, Characterization of CBGs/Their Lithium Salts and CBG Li Catalyzed Addition of B?H and TMSCN to Carbonyls

Herein, we report a range of conjugated bis-guanidines (CBGs) L [L={(ArHN)(ArHN)C=N?C=(NAr)(NHAr)}; Ar=2, 6-Me2 - C6H3, (1), 2, 4, 6-Me3?C6H2, (2), 2, 6-Et2?C6H3

Pyrene carboxylate ligand based coordination polymers for microwave-assisted solvent-free cyanosilylation of aldehydes

The new coordination polymers (CPs) [Zn(μ-1κO1:1κO2-L)(H2O)2]n·n(H2O) (1) and [Cd(μ4-1κO1O2:2κN:3,4κO3-L)(H2O)]n·n(H2

Alkoxo bridged heterobimetallic CoIIISnIV compounds with face shared coordination octahedra: Synthesis, crystal structure and cyanosilylation catalysis

The self-assembly reaction of the Schiff base N,N’-ethylenebis(2-hydroxyacetophenoneimine) (H2L), CoCl2··6H2O and [SnPh2Cl2] led to the alkoxo-bridged heteroorganometallic CoIIISnIV/s

n-Butyllithium as a highly efficient precatalyst for cyanosilylation of aldehydes and ketones

A highly efficient cyanosilylation protocol mediated by the easily availablen-BuLi with a wide range of aldehydes and ketones was developed. This protocol features excellent yields with very lown-BuLi loadings (0.01-0.05 mol%) at room temperature, solvent