97379-28-7

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 24588-72-5 2-(4-methoxyphenyl)-1,3-dithiane 
• 75748-09-3 (4-methoxybenzoyl)trimethylsilane 
• 1122-91-4 4-bromo-benzaldehyde 
• 673-40-5 4-bromobenzenediazonium tetrafluoroborate 
• 768-60-5 4-methoxyphenylacetylen 
• 83575-55-7 2-(4-bromophenyl)-2-(trimethylsilyloxy)acetonitrile 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Downstream Products

• 1001014-56-7 4-(4-bromophenyl)-5-(4-methoxyphenyl)-2-(thiophen-2-yl)-1H-imidazole 

Relevant academic research and scientific papers

Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement

α-Imino ketone is a useful building block for the preparation of α-amino ketones and α-amino alcohols. However, its preparation has been seldomly seen. Herein, a metal-free and operationally simple strategy has been developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.

Visible Light Enabled Formal Cross Silyl Benzoin Reaction as an Access to α-Hydroxyketones

In this work, a visible-light enabled coupling of acylsilanes with aldehydes to give a range of cross-benzoin type products α-hydroxyketones is described. The reaction could proceed at ambient temperature, with the irradiation of low energy visible light, and without addition of photosensitizer or any other additives. (Figure presented.).

Benzofuran-2-ketone compound as well as preparation method and application thereof

The invention discloses a benzofuran-2-ketone compound as well as a preparation method and application thereof, and belongs to the technical field of medicine. The benzofuran-2-ketone compound is prepared from benzoin compounds containing different substituent groups and resorcinol serving as raw materials, sodium hydroxide serving as alkali and glycerol serving as a solvent by one step of performing reaction at 120 DEG C for 12 hours under the catalysis of an onium salt catalyst 3-benyl-5-(2-ethoxyl)-4-methyl thiazoline chloride. The compound has certain inhibition activity on prostate cancercells DU-145, neuroglioma cells U-87 and breast cancer cells MCF-7. Compared with the prior art, the preparation method is more convenient and environmentally friendly.

De Novo Synthesis of α-Hydroxy Ketones by Gallic Acid-Promoted Aerobic Coupling of Terminal Alkynes with Diazonium Salts

An unprecedented metal-free direct preparation of unprotected α-hydroxy ketones from terminal alkynes under mild conditions with diazonium salts as the arene source and without the requirement of irradiation is described. The process is general and fully compatible with a wide variety of substitution in both reactants. Experimental and computational evidence strongly suggest the involvement of radical species in the transformation.

SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS

The invention pertains to heteroaromatic compounds of the formula I, as defined herein, that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.