83702-21-0Relevant academic research and scientific papers
Expeditious Synthesis of 2-Phenylquinazolin-4-amines via a Fe/Cu Relay-Catalyzed Domino Strategy
Jia, Feng-Cheng,Zhou, Zhi-Wen,Xu, Cheng,Cai, Qun,Li, Deng-Kui,Wu, An-Xin
, p. 4236 - 4239 (2015)
A highly efficient Fe/Cu relay-catalyzed domino protocol has been developed for the synthesis of 2-phenylquinazolin-4-amines from commercially available ortho-halogenated benzonitriles, aldehydes, and sodium azide. This elegant domino process involved con
Efficient synthesis of 2-arylquinazolin-4-amines via a copper-catalyzed diazidation and ring expansion cascade of 2-arylindoles
Xu, Meng-Meng,Cao, Wen-Bin,Xu, Xiao-Ping,Ji, Shun-Jun
supporting information, p. 12602 - 12605 (2018/11/20)
Copper-catalyzed synthesis of 2-arylquinazolin-4-amines from readily available 2-arylindoles and TMSN3 has been developed. The mechanism study shows that the domino reaction may involve a free radical diazidation, denitrogenation, intramolecular cyclization and ring expansion sequence.
A Highly Efficient Copper-Catalyzed Three-Component Synthesis of 4-Aminoquinazolines
Yang, Lei,Luo, Honghua,Sun, Yan,Shi, Zhenyu,Ni, Kaidong,Li, Fei,Chen, Dongyin
, p. 2535 - 2535 (2017/05/22)
A highly efficient copper-catalyzed one-pot protocol is developed for the synthesis of 4-aminoquinazolines from easily available 2-iodo- or 2-bromobenzimidamides, aldehydes, and sodium azide. This one-pot approach proceeds via consecutive copper-catalyzed SNAr substitution, reduction, cyclization, oxidation and tautomerization. The corresponding target products (26 examples) are obtained in 50-90% yield.
Synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles under catalyst-free conditions
Feng, Jian-Bo,Wu, Xiao-Feng
supporting information, p. 10656 - 10662 (2015/11/17)
A convenient procedure for the synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles has been developed. By using KOtBu as the promotor with 2-aminopyridines or amidines as the reaction partner, the desired heterocycles
Dawson heteropolyacid: A green, eco-friendly, and reusable catalyst for one-pot synthesis of 4-aminoquinazolines
Bamoharram, Fatemeh F.,Heravi, Majid M.,Roshani, Mina,Kosari, Katayon
, p. 539 - 542 (2013/06/27)
A new multicomponent synthesis of 4-aminoquinazolines from the reaction of anthranilonitrile, acylchlorides, and ammonium acetate in the presence of catalytic amounts of Dawson-type heteropolyacids (HPAs) is reported. The catalytic performance of different forms of Dawson-type HPAs, H6 P2M18O62 (M = WVI, MoVI) and mixed addenda forms (M = CoII, CuII, NiII, MnIII) were compared and in all cases, maximum of yield was observed by using H6P2W18O62 as catalyst. The plausible mechanism was estimated. In all cases, the Dawson catalyst was easily recovered and recycled with retention of their initial structure and activity. The effects of reaction conditions have been studied and the results showed yields of reaction are good to excellent. Copyright Taylor and Francis Group, LLC.
Efficient three-component synthesis of 4-aminoquinazolines
Heravi, Majid M.,Sadjadi, Samaheh,Haj, Negar Mokhtari,Oskooie, Hossein A.,Bamoharram, Fatemeh F.
experimental part, p. 861 - 867 (2010/05/18)
4-Aminoquinazolines were synthesized in good yields via a one-pot, three-component reaction of anthranilonitrile, acylchlorides, and ammonium acetate in the presence of catalytic amounts silica-supported Preyssler nanoparticles under refluxing conditions.
Hydroxide-Catalyzed Synthesis of Heterocyclic Aromatic Amine Derivatives from Nitriles
Smyrl, Norman R.,Smithwick, Robert W.
, p. 493 - 496 (2007/10/02)
A generalized method for synthesizing a wide variety of heterocyclic aromatic amine derivatives from nitriles by use of hydroxide catalysts is presented.Nitrile dimers (3-aminocrotononitrile and dicyandiamide) and a dimer analog (anthranilonitrile) react with monomeric nitriles in the presence of hydroxide to form respectively, aminopyrimidines, diaminotriazines and aminoquinazolines.
