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83710-62-7

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83710-62-7 Usage

General Description

6-Methoxy-1-bromo naphthalene is a chemical compound consisting of a naphthalene ring with a methoxy group and a bromine atom attached to it. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and pigments. 6-METHOXY-1-BROMO NAPHTHALENE is known for its high reactivity and is often used in organic synthesis for the preparation of various organic compounds. It is also a potential environmental contaminant and its impact on human health and the environment should be carefully studied and monitored.

Check Digit Verification of cas no

The CAS Registry Mumber 83710-62-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,7,1 and 0 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 83710-62:
(7*8)+(6*3)+(5*7)+(4*1)+(3*0)+(2*6)+(1*2)=127
127 % 10 = 7
So 83710-62-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H9BrO/c1-13-9-5-6-10-8(7-9)3-2-4-11(10)12/h2-7H,1H3

83710-62-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-bromo-6-methoxynaphthalene

1.2 Other means of identification

Product number -
Other names (5-Brom-[2]naphthyl)-methyl-aether

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:83710-62-7 SDS

83710-62-7Relevant articles and documents

TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND

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Paragraph 0144; 0146, (2021/07/17)

Disclosed is a series of tricyclic substituted piperidine dione compounds, and applications thereof in the preparation of medicines for treating diseases related to CRBN protein; specifically disclosed are the derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

PYRAZOLE-CONTAINING MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS

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Page/Page column 102; 103, (2019/10/04)

In one aspect, the invention comprises compounds that bind and inhibit macrophage migration inhibitory factor. In another aspect, the invention provides methods of treating inflammatory disease, neurological disorders and cancer using the compounds of the invention.

Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor

Trivedi-Parmar, Vinay,Robertson, Michael J.,Cisneros, José A.,Krimmer, Stefan G.,Jorgensen, William L.

, p. 1092 - 1097 (2018/04/30)

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is implicated in the regulation of inflammation, cell proliferation, and neurological disorders. MIF is also an enzyme that functions as a keto–enol tautomerase. Most potent MIF tautomerase inhibitors incorporate a phenol, which hydrogen bonds to Asn97 in the active site. Starting from a 113-μm docking hit, we report results of structure-based and computer-aided design that have provided substituted pyrazoles as phenol alternatives with potencies of 60–70 nm. Crystal structures of complexes of MIF with the pyrazoles highlight the contributions of hydrogen bonding with Lys32 and Asn97, and aryl–aryl interactions with Tyr36, Tyr95, and Phe113 to the binding.

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